Acute intraocular toxicity caused by perfluorocarbon liquids: safety control systems of medical devices
| العنوان: | Acute intraocular toxicity caused by perfluorocarbon liquids: safety control systems of medical devices |
|---|---|
| المؤلفون: | Girish K. Srivastava, Vivekanandan Kalaiselvan, Cristina Andrés-Iglesias, Shatrunajay Shukla, Rohit Saxena, Jose Carlos Pastor |
| المصدر: | Graefe's Archive for Clinical and Experimental Ophthalmology |
| بيانات النشر: | Springer Berlin Heidelberg, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | PFO clinical cases, Direct cytotoxicity test, Fluorocarbons, Retinal Detachment, PFO toxicity, ISO guidelines, Review Article, Sensory Systems, Cellular and Molecular Neuroscience, Ophthalmology, Middle East, Italy, Retinal toxicity, Spain, Humans, France |
| الوصف: | Background Acute retinal toxicity has been demonstrated to be associated with the intraoperative use of perfluorocarbon liquids (PFCLs), especially perfluorooctane (PFO). Recently, several cases of PFO-associated blindness have been reported in Spain, Holland, France, Italy, the Middle East, and South America. Methods As a result, a new ISO guideline (ISO 16672:2020) was drafted, discussed, approved, and released in 2019. This recent ISO16672:2020 guideline recommends performing direct cytotoxicity tests as an option along with chemical analysis to measure PFCL quality (purity and safety). Results In this review paper, it has been emphasized why an appropriate biological test, specifically direct exposure of PFCL to live cells, for measuring cytotoxicity must be performed with each PFCL batch along with chemical analysis. Conclusions The paper intends to compile all available information to discuss possible approaches for avoiding adverse clinical cases in future. |
| اللغة: | English |
| تدمد: | 1435-702X 0721-832X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb24ed35f5a308d07a67371ec286ed2b http://europepmc.org/articles/PMC8817148 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb24ed35f5a308d07a67371ec286ed2b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1435702X 0721832X |
|---|