ς1Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward
| العنوان: | ς1Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward |
|---|---|
| المؤلفون: | Wayne D. Bowen, Rémi Martin-Fardon, Pascal Romieu, Tangui Maurice |
| المصدر: | The Journal of Neuroscience. 23:3572-3576 |
| بيانات النشر: | Society for Neuroscience, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Cyclopropanes, Male, Agonist, medicine.medical_specialty, Neuroactive steroid, medicine.drug_class, Dehydroepiandrosterone, Motor Activity, Pharmacology, Brief Communication, Cocaine-Related Disorders, Mice, Igmesine, Cocaine, Reward, Internal medicine, Conditioning, Psychological, medicine, Animals, Receptors, sigma, Enzyme Inhibitors, Progesterone, Sigma-1 receptor, Behavior, Animal, Chemistry, General Neuroscience, Finasteride, Antagonist, Drug Synergism, Conditioned place preference, Mice, Inbred C57BL, Endocrinology, Cinnamates, Pregnenolone, Steroids, Disease Susceptibility, Drug Antagonism, medicine.drug |
| الوصف: | The sigma1 receptor is critically involved in the rewarding effect of cocaine, as measured using the conditioned place preference (CPP) procedure in mice. Neuroactive steroids exert rapid neuromodulatory effects in the brain by interacting with GABA(A), NMDA, and sigma1 receptors. At the sigma1 receptor level, 3beta-hydroxy-5-androsten-17-one [dehydroepiandrosterone (DHEA)] and 3beta-hydroxy-5-pregnen-20-one (pregnenolone) act as agonists, whereas 4-pregnene-3,20-dione (progesterone) is an efficient antagonist. The present study sought to investigate the action of neuroactive steroids in acquisition of cocaine-induced CPP in C57BL/6 mice. None of these steroids induced CPP alone. However, pretreatment with DHEA or pregnenolone (5-20 mg/kg, s.c.) during conditioning with cocaine (10 mg/kg, i.p.) increased the conditioned score. On the contrary, pretreatment with either progesterone (10 or 20 mg/kg, s.c.) or finasteride (25 mg/kg, twice a day), a 5alpha-reductase inhibitor, blocked acquisition of cocaine (20 mg/kg)-induced CPP. A crossed pharmacology was observed between steroids and sigma1 ligands. The sigma1 antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine blocked cocaine-induced CPP and its potentiation by DHEA or pregnenolone. Progesterone blocked cocaine-induced CPP and its potentiation by the sigma1 agonist igmesine. These results showed that neuroactive steroids play a role in cocaine-induced appetence, through their interaction with the sigma1 receptor. Therefore, neuroendocrine control of cocaine addiction may not involve solely glucocorticoids. The importance of neuroactive steroids as factors of individual vulnerability to drug addiction should, thus, be considered. |
| تدمد: | 1529-2401 0270-6474 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2efea3188090a5824c3ee5bb7d2f6b https://doi.org/10.1523/jneurosci.23-09-03572.2003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb2efea3188090a5824c3ee5bb7d2f6b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
|---|