Treatment with Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis: Comparison Between Private Rheumatology Practices and Academic Centers in a Large Observational Cohort
| العنوان: | Treatment with Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis: Comparison Between Private Rheumatology Practices and Academic Centers in a Large Observational Cohort |
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| المؤلفون: | Pascale Exer, Rudolf O. Kissling, Ulrich Weber, Beat A. Michel, Peter M. Villiger, Martin Toniolo, Almut Scherer, Adrian Ciurea, Jürg Bernhard, Pascal Zufferey, Daniel J. Stekhoven, Giorgio Tamborrini |
| المساهمون: | University of Zurich, Ciurea, Adrian |
| المصدر: | Ciurea, A, Weber, U, Stekhoven, D, Scherer, A, Tamborrini, G, Bernhard, J, Toniolo, M, Villiger, P M, Zufferey, P, Kissling, R O, Michel, B A & Exer, P 2015, ' Treatment with tumor necrosis factor inhibitors in axial spondyloarthritis : Comparison between private rheumatology practices and academic centers in a large observational cohort ', Journal of Rheumatology, vol. 42, no. 1, pp. 101-105 . https://doi.org/10.3899/jrheum.140229 |
| بيانات النشر: | The Journal of Rheumatology, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, 2745 Rheumatology, Immunology, Private Practice, 610 Medicine & health, Antirheumatic Agents/therapeutic use, Rheumatology, Internal medicine, Spondylarthritis, Humans, Immunology and Allergy, Medicine, Practice Patterns, Physicians', Axial spondyloarthritis, BASDAI, Spondylarthritis/drug therapy, 2403 Immunology, Academic Medical Centers, Ankylosing spondylitis, Tumor Necrosis Factor-alpha/antagonists & inhibitors, Tumor Necrosis Factor-alpha, business.industry, 10051 Rheumatology Clinic and Institute of Physical Medicine, Middle Aged, medicine.disease, University hospital, adult ankylosing spondylitis Ankylosing Spondylitis Disease Activity Score article cohort analysis *comparative study controlled study female follow up functional assessment human major clinical study male middle aged observational study *private hospital *spondylarthritis/dt [Drug Therapy] treatment indication treatment outcome treatment response *university hospital disease modifying antirheumatic drug/dt [Drug Therapy] nonsteroid antiinflammatory agent/dt [Drug Therapy] *tumor necrosis factor inhibitor/dt [Drug Therapy], Treatment Outcome, Antirheumatic Agents, Cohort, 2723 Immunology and Allergy, Physical therapy, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center, Female, Tumor necrosis factor alpha, Observational study, business |
| الوصف: | Objective.To evaluate the initiation of and response to tumor necrosis factor (TNF) inhibitors for axial spondyloarthritis (axSpA) in private rheumatology practices versus academic centers.Methods.We compared newly initiated TNF inhibition for axSpA in 363 patients enrolled in private practices with 100 patients recruited in 6 university hospitals within the Swiss Clinical Quality Management (SCQM) cohort.Results.All patients had been treated with ≥ 1 nonsteroidal antiinflammatory drug and > 70% of patients had a baseline Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4 before anti-TNF agent initiation. The proportion of patients with nonradiographic axSpA (nr-axSpA) treated with TNF inhibitors was higher in hospitals versus private practices (30.4% vs 18.7%, p = 0.02). The burden of disease as assessed by patient-reported outcomes at baseline was slightly higher in the hospital setting. Mean levels (± SD) of the Ankylosing Spondylitis Disease Activity Score were, however, virtually identical in private practices and academic centers (3.4 ± 1.0 vs 3.4 ± 0.9, p = 0.68). An Assessment of SpondyloArthritis international Society (ASAS40) response at 1 year was reached for ankylosing spondylitis in 51.7% in private practices and 52.9% in university hospitals (p = 1.0) and for nr-axSpA in 27.5% versus 25.0%, respectively (p = 1.0).Conclusion.With the exception of a lower proportion of patients with nr-axSpA newly treated with anti-TNF agents in private practices in comparison to academic centers, adherence to ASAS treatment recommendations for TNF inhibition was equally high, and similar response rates to TNF blockers were achieved in both clinical settings. |
| تدمد: | 1499-2752 0315-162X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb400ecdefcf2a6b238cc093810195c8 https://doi.org/10.3899/jrheum.140229 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb400ecdefcf2a6b238cc093810195c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14992752 0315162X |
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