Molecular epidemiology and phylogeography ofSchistosoma mansoniaround Lake Victoria
| العنوان: | Molecular epidemiology and phylogeography ofSchistosoma mansoniaround Lake Victoria |
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| المؤلفون: | Narcis B. Kabatereine, Charles N. Lange, Claire J. Standley, Nicholas J.S. Lwambo, J. R. Stothard |
| المصدر: | Parasitology. 137:1937-1949 |
| بيانات النشر: | Cambridge University Press (CUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Molecular Sequence Data, Population, Population genetics, Zoology, Helminth genetics, Biology, Tanzania, DNA barcoding, Evolution, Molecular, Geographical distance, parasitic diseases, Animals, DNA Barcoding, Taxonomic, Humans, Uganda, Child, education, Molecular Epidemiology, education.field_of_study, Molecular epidemiology, Ecology, Genetic Variation, Schistosoma mansoni, Sequence Analysis, DNA, DNA, Helminth, Kenya, Schistosomiasis mansoni, Phylogeography, Infectious Diseases, Child, Preschool, Genetic structure, Animal Science and Zoology, Parasitology, Sequence Analysis, Microsatellite Repeats |
| الوصف: | SUMMARYIntestinal schistosomiasis continues to be a major public health problem in sub-Saharan Africa, and is endemic in communities around Lake Victoria. Interest is growing in the molecular evolution and population genetic structure ofSchistosoma mansoniand we describe a detailed analysis of the molecular epidemiology and phylogeography ofS. mansonifrom Lake Victoria. In total, 388 cytochrome oxidase 1 (COI) sequences were obtained from 25 sites along the Ugandan, Tanzanian and Kenyan shorelines of Lake Victoria, and 122 unique barcodes were identified; 9 corresponded to previously discovered barcodes from Lakes Victoria and Albert. A subset of the data, composed of COI sequences from miracidia from 10 individual children, was used for population genetics analyses; these results were corroborated by microsatellite analysis of 4 isolates of lab-passaged adult worms. Overall, 12 barcodes were found to be shared across all 3 countries, whereas the majority occurred singly and were locally restricted. The population genetics analyses were in agreement in revealing high diversity at the level of the human host and negligible population structuring by location. The lack of correlation between genetic distance and geographical distance in these data may be attributed to the confounding influence of high intra-individual diversity as well as human migration between communities. |
| تدمد: | 1469-8161 0031-1820 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4bc65d6f3b24a64536ce39ec8a0343 https://doi.org/10.1017/s0031182010000788 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bb4bc65d6f3b24a64536ce39ec8a0343 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698161 00311820 |
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