التفاصيل البيبلوغرافية
العنوان:
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist
المؤلفون:
William F. Hodnick , Luis Llamas , Thomas C. Dent , Jianping Song , Youssef L. Bennani , Michael J. Robarge , John J. Harrington , Alain Stricker-Krongrad , Kurt R. Brunden , Bayard Huck , Chris Crumrine
المصدر:
Bioorganic & Medicinal Chemistry Letters . 16:4130-4134
بيانات النشر:
Elsevier BV, 2006.
سنة النشر:
2006
مصطلحات موضوعية:
Agonist , Nitrogen , medicine.drug_class , Clinical Biochemistry , Pharmaceutical Science , Biochemistry , Chemical synthesis , Structure-Activity Relationship , Dogs , Drug Discovery , medicine , Animals , Structure–activity relationship , Receptor , Molecular Biology , G protein-coupled receptor , chemistry.chemical_classification , Organic Chemistry , Biological activity , Feeding Behavior , Rats , Serotonin Receptor Agonists , chemistry , Drug Design , Molecular Medicine , 5-HT2C receptor agonist , Serotonin 5-HT2 Receptor Agonists , Half-Life , Tricyclic
الوصف:
5-HT2C agonists have shown efficacy in limiting food consumption and thus may serve as an important drug class in combating obesity. We describe the design and synthesis of a novel tricyclic single-nitrogen scaffold that was used to produce 5-HT2C agonists. SAR was developed around this chemotype and compounds were identified that were potent (Ki
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4d223bc94b862932530d77cc884be5 https://doi.org/10.1016/j.bmcl.2006.04.070
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....bb4d223bc94b862932530d77cc884be5
قاعدة البيانات:
OpenAIRE
