Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma
| العنوان: | Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is Associated with a Poor Prognosis in Esophageal Squamous Cell Carcinoma |
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| المؤلفون: | Tadashi Shiraishi, Takeshi Toyozumi, Haruhito Sakata, Kentaro Murakami, Masayuki Kano, Yasunori Matsumoto, Masaya Yokoyama, Koichiro Okada, Toshiki Kamata, Takahiro Ryuzaki, Kazuya Kinoshita, Soichiro Hirasawa, Hisahiro Matsubara |
| المصدر: | Oncology. 100:39-47 |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Mice, Inbred BALB C, Cancer Research, Esophageal Neoplasms, Mice, Nude, General Medicine, Middle Aged, Prognosis, Xenograft Model Antitumor Assays, B7-H1 Antigen, Survival Rate, Solubility, Oncology, Cell Line, Tumor, mental disorders, Biomarkers, Tumor, Animals, Humans, Female, Esophageal Squamous Cell Carcinoma, Aged |
| الوصف: | Introduction: We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Methods: Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-L1 concentration and the expression of PD-L1 in tumor specimens and tumor depth, lymph node metastasis, disease stage, and various laboratory data were assessed. Results: sPD-L1 levels in patients with high PD-L1 expression levels in tumor tissue were significantly higher than in patients with low PD-L1 expression levels (p = 0.042). The OS of the sPD-L1-high group was significantly worse than that of the low group (p = 0.028). Similarly, patients in whom a tissue specimen was PD-L1-positive group showed significantly poorer OS. Conclusion: The sPD-L1 concentration was correlated with the PD-L1 expression in tissues. Patients with PD-L1-positive tissue specimens showed significantly higher sPD-L1 levels in comparison to PD-L1-negative cases. Furthermore, patients with high sPD-L1 expression levels had a significantly worse prognosis than those with low sPD-L1 expression levels, and patients with a PD-L1-positive tissue specimen had a significantly worse prognosis than patients in whom the tissue specimen showed a low PD-L1 expression level. |
| تدمد: | 1423-0232 0030-2414 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb57e9eece35ab4551d077b0c5efcd9c https://doi.org/10.1159/000518740 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bb57e9eece35ab4551d077b0c5efcd9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230232 00302414 |
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