Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ~propensity score- matched analysis~
| العنوان: | Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ~propensity score- matched analysis~ |
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| المؤلفون: | Tetsuro Nagasaka, Kiyosumi Shibata, Michiyasu Kawai, Shiro Suzuki, Hiroaki Kajiyama, Nobuhisa Yoshikawa, Fumitaka Kikkawa, Osamu Yamamuro, Kimio Mizuno |
| المصدر: | BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019) BMC Cancer |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Adult, Risk, Cancer Research, medicine.medical_specialty, Fertility-sparing surgery, Propensity score, lcsh:RC254-282, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Recurrence, Internal medicine, Genetics, medicine, Humans, Overall survival, Radical surgery, Stage (cooking), Neoplasm Staging, Retrospective Studies, Ovarian Neoplasms, 030219 obstetrics & reproductive medicine, Epithelial ovarian carcinoma, business.industry, Medical record, Fertility Preservation, Middle Aged, medicine.disease, Recurrence-free survival, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Survival Rate, 030220 oncology & carcinogenesis, Cohort, Propensity score matching, Female, Neoplasm Recurrence, Local, business, Ovarian cancer, Cohort study, Research Article |
| الوصف: | Background The aim of this study was to investigate how much the risks of recurrence and death are increased as a consequence of selecting fertility-sparing surgery (FSS) in young women with epithelial ovarian cancer (EOC). Methods After a central pathological review and search of the medical records from 14 collaborating hospitals, a non-randomized, observational cohort study was conducted between 1987 and 2015, including 1183 women with stage I EOC. Finally, a total of 285 patients with stage I EOC at reproductive age were recruited. Oncologic outcomes were compared between the FSS (N = 101) and radical surgery (RS) group (N = 184) using a propensity score (PS)-matching technique to adjust for relevant risk factors: the age, substage, histological type, grade, CA125 values, ascites cytology, ascites volume, and chemotherapy. Results During 66.0 months (median) of follow-up, 42 patients (14.7%) developed recurrence, and 31 patients (10.9%) died. In the original cohort, there was no significant difference in overall survival (OS) or recurrence-free survival (RFS) between the FSS and RS groups {Log-rank: OS (P = 0.838), RFS (P = 0.377)}. In the PS-matched cohort after adjustment for multiple clinicopathologic factors, there was no significant difference in RFS or OS between the FSS and RS groups {RFS (FSS vs. RS), HR: 1.262 (95% CI: 0.559–2.852), P = 0. 575; OS (FSS vs. RS), HR: 1.206 (95% CI: 0.460–3.163), P = 0.704}. Conclusions After adjustment for clinicopathologic factors, FSS in itself may not worsen the oncologic outcome in young women with early-stage EOC. A large-scale clinical study is necessary to validate the findings. |
| اللغة: | English |
| تدمد: | 1471-2407 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6a94f6cdb9b7f99ae07dbabdc01ccb https://doaj.org/article/3a3f50b2056b4ad5a4759f7d1f37bad3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb6a94f6cdb9b7f99ae07dbabdc01ccb |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712407 |
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