EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE
| العنوان: | EFFICACY OF RUFINAMIDE IN THE TREATMENT OF DRUG-RESISTANT FOCAL EPILEPSIES IN PAEDIATRIC PRACTICE |
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| المؤلفون: | I. O. Shchederkina, K. A. Orlova, I. E. Koltunov, M. Yu. Dorofeeva |
| المصدر: | Russkij Žurnal Detskoj Nevrologii, Vol 11, Iss 4, Pp 54-60 (2017) |
| بيانات النشر: | Publishing House ABV Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, rufinamide, Atypical absence seizures, inovelon, Rufinamide, Status epilepticus, Disease, lennox–gastaut syndrome, Epilepsy, drug-resistant epilepsy, medicine, polymorphic seizures, RC346-429, business.industry, medicine.disease, Drug Resistant Epilepsy, Anesthesia, Pediatrics, Perinatology and Child Health, Etiology, Neurology. Diseases of the nervous system, Neurology (clinical), medicine.symptom, business, medicine.drug, Lennox–Gastaut syndrome |
| الوصف: | Among drug-resistant epilepsies, epileptic syndromes, characterized by combination of several types of seizures, are considered to be the most difficult in terms of treatment. Lennox–Gastaut syndrome is one of them. It manifests with polymorphic seizures (tonic axial, myatonic, atypical absence seizures, status epilepticus of minor motor seizures, myoclonic, generalized convulsive, and focal seizures). This is a heterogeneous disease, represented by a complex of clinical and electroencephalographic manifestations with various etiology. Current review is devoted to a novel antiepileptic drug rufinamide, which has a new mechanism of action. The drug has been registered in Russia in 2015. The authors also describe their own experience of rufinamide usage in the treatment of drug-resistant focal epilepsy as a part of multicomponent therapy for polymorphic seizures. One patient achieved clinical remission for 16 months; the second one had more than 50 % decrease in seizures frequency with a remission of drop-attacks. |
| تدمد: | 2412-9178 2073-8803 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7d85293383d16d0676589ee5eb0930 https://doi.org/10.17650/2073-8803-2016-11-4-54-60 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb7d85293383d16d0676589ee5eb0930 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24129178 20738803 |
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