Changes of T Lymphocyte Subsets in Peripheral Blood of Patients with Intermediate and Advanced Cervical Cancer before and after Nimotuzumab Combined with Chemoradiotherapy
| العنوان: | Changes of T Lymphocyte Subsets in Peripheral Blood of Patients with Intermediate and Advanced Cervical Cancer before and after Nimotuzumab Combined with Chemoradiotherapy |
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| المؤلفون: | Fei, Teng, Guimin, Cui, Ligang, Qian, Lujun, Zhao |
| المصدر: | International Archives of Allergy and Immunology. 184:85-97 |
| بيانات النشر: | S. Karger AG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Leptin, Th2 Cells, T-Lymphocyte Subsets, Immunology, Humans, Uterine Cervical Neoplasms, Immunology and Allergy, Female, Chemoradiotherapy, General Medicine, Carcinoembryonic Antigen |
| الوصف: | Introduction: Cervical cancer (CC) is the main malignant tumor of gynecology with high mortality. This study aimed to explore the changes of T lymphocyte subsets in the peripheral blood of patients with intermediate and advanced CC (IACC) treated with nimotuzumab (Nimo) combined with chemoradiotherapy (CRT). Methods: Peripheral blood was extracted before and after treatment, and patients were randomly divided into the CRT group (N = 68) or the Nimo + CRT group (N = 68). The levels of tumor markers squamous cell carcinoma antigen (SCCA), carbohydrate antigen 125 (CA125), and carcinoembryonic antigen (CEA), tumor indexes leptin and insulin-like growth factor-2 (IGF2), and key secretory factors (interferon γ/tumor necrosis factor α/interleukin (IL)-4/IL-13) of Th1 and Th2 cells in the serum were detected. The levels of T lymphocyte subsets CD3+, CD4+, CD8+, and CD4+/CD8+ and the levels of Th1/Th2 and Th17/Treg in CD4+ cell subsets were determined by flow cytometry. The objective remission rate, progression-free survival (PFS), and overall survival (OS) of patients were analyzed, and Kaplan-Meier curves were drawn to show the prognosis of patients. Results: After treatment, the levels of SCCA, CA125, CEA, leptin, and IGF2 in the serum of patients with IACC were decreased, the level of Th1/Th2 was increased, and the Th17/Treg level was decreased. The treatment effect of Nimo + CRT was more significant than that of CRT alone. Survival curve analysis showed that Nimo + CRT could prolong PFS and OS in patients with IACC. In addition, the follow-up results of patients showed that Nimo did not increase the incidence and severity of adverse reactions caused by CRT. Conclusion: Nimo combined with CRT can protect the immune function of patients, improve the effective rate, and prolong the survival rate of patients with IACC. |
| تدمد: | 1423-0097 1018-2438 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7e0ae111a641d0fc3305957cbcb828 https://doi.org/10.1159/000525487 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bb7e0ae111a641d0fc3305957cbcb828 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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