The Benefit of Fentanyl in Effective Sedation and Quality of Upper Endoscopy: A Double-Blinded Randomized Trial of Fentanyl Added to Midazolam Versus Midazolam Alone for Sedation
| العنوان: | The Benefit of Fentanyl in Effective Sedation and Quality of Upper Endoscopy: A Double-Blinded Randomized Trial of Fentanyl Added to Midazolam Versus Midazolam Alone for Sedation |
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| المؤلفون: | Subhas C. Ganguli, S. Jalali, R Spaziani, Keith Tsoi, David Morgan, H Fergani, Khurram J. Khan |
| المصدر: | Journal of the Canadian Association of Gastroenterology |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Sedation, Placebo, law.invention, Fentanyl, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Medicine, Retching, medicine.diagnostic_test, business.industry, Endoscopy, Original Articles, Quality, Clinical trial, 030220 oncology & carcinogenesis, Anesthesia, Midazolam, 030211 gastroenterology & hepatology, medicine.symptom, business, medicine.drug |
| الوصف: | Aims Our goals were to compare the effect of adding fentanyl to midazolam in a double-blinded, randomized, placebo-controlled trial and determine if fentanyl enhances sedation, increases adverse events or effects time of the procedure or discharge. Methods Patients 18 to 65 years scheduled for outpatient upper endoscopy were eligible for the study. Patients were randomized to receive either 100 mcg/2 mL of Fentanyl or 2 mL of placebo IV with a double-blinded protocol. All patients received 2 mg of intravenous midazolam initially. Additional midazolam could be given to achieve adequate sedation. Results There were 68 patients randomized to the Fentanyl group and 69 patients to the placebo group. The mean dose of midazolam was 4.0 mg for the Fentanyl group and 5.2 mg for placebo group (P=0.003). Both endoscopist and nurse independently rated sedation to be better in the fentanyl group (P=0001). The patient did not perceive any difference in sedation (P=0.4). Procedure time was significantly shorter in the Fentanyl group (8.5 versus 11.1 minutes, P=0.001), with no difference in the discharge time. There was significantly less retching observed in patients in the fentanyl group (P |
| تدمد: | 2515-2092 2515-2084 0151-4695 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8c6d90e386a708cc76ef08f51d58a3 https://doi.org/10.1093/jcag/gwy041 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb8c6d90e386a708cc76ef08f51d58a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25152092 25152084 01514695 |
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