Results: Individuals with elevated levels of hs-CRP of greater than 3 mg/L had a 1.6and 1.3-fold increased risk for ischemic heart disease and ischemic cerebrovascular disease, respectively, compared with individuals with hs-CRP of less than 1 mg/L. Individuals with hs-CRP polymorphism had a 64% increase in hs-CRP, but this was not associated with increased cardiovascular events. In contrast, individuals with apolipoprotein E polymorphism had elevated cholesterol levels and increased risk for ischemic heart disease.