Retention of Somatic Memory Associated with Cell Identity, Age and Metabolism in Induced Pluripotent Stem (iPS) Cells Reprogramming
| العنوان: | Retention of Somatic Memory Associated with Cell Identity, Age and Metabolism in Induced Pluripotent Stem (iPS) Cells Reprogramming |
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| المؤلفون: | Nor Azian Abdul Murad, Hafiza Alauddin, Rahman Jamal, Nur Azurah Abdul Ghani, Noor Hamidah Hussin, Tze Sean Khoo |
| المصدر: | Stem Cell Reviews and Reports. 16:251-261 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell type, Somatic cell, Induced Pluripotent Stem Cells, Biology, Cellular Reprogramming, Embryonic stem cell, Regenerative medicine, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Animals, Humans, Epigenetics, Stem cell, Induced pluripotent stem cell, Reprogramming, Cellular Senescence |
| الوصف: | The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted them enormous potential in many applications, particularly regenerative therapy. Unlike ES cells, however, iPS cells exhibit somatic memories which were carried over from the tissue of origin thus limited its translation in clinical applications. This review provides an updated overview of the retention of various somatic memories associated with the cellular identity, age and metabolism of tissue of origin in iPS cells. The influence of cell types, stage of maturation, age and various other factors on the retention of somatic memory has been discussed. Recent evidence of somatic memory in the form of epigenetic, transcriptomic, metabolic signatures and its functional manifestations in both in vitro and in vivo settings also have been reviewed. The increasing number of studies which had adopted isogenic cell lines for comparisons in recent years had facilitated the identification of genuine somatic memories. These memories functionally affect iPS cells and its derivatives and are potentially tumorigenic thus, raising concerns on their safety in clinical application. Various approaches for memory erasure had since being reported and their efficacies were highlighted in this review. |
| تدمد: | 2629-3277 2629-3269 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdde54d577ce185922b6f2256a1ef46 https://doi.org/10.1007/s12015-020-09956-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bbdde54d577ce185922b6f2256a1ef46 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 26293277 26293269 |
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