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Isolated periventricular pseudocysts do not affect white matter microstructure development in neonatal stage: A retrospective case-control diffusion tensor imaging study

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العنوان: Isolated periventricular pseudocysts do not affect white matter microstructure development in neonatal stage: A retrospective case-control diffusion tensor imaging study
المؤلفون: Fan Wu, Yuli Zhang, Congcong Liu, Xiaoyu Wang, Huifang Zhao, Yannan Cheng, Xingxing Tao, Miaomiao Wang, Jian Yang, Heng Liu, Xianjun Li, Chao Jin
المصدر: European Journal of Radiology. 116:152-159
بيانات النشر: Elsevier BV, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, Encephalopathy, Germinal matrix, 030218 nuclear medicine & medical imaging, White matter, 03 medical and health sciences, 0302 clinical medicine, Fractional anisotropy, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Neonatal stage, Retrospective Studies, Brain Diseases, Cysts, business.industry, Radial diffusivity, Infant, Newborn, General Medicine, medicine.disease, White Matter, White matter microstructure, Diffusion Tensor Imaging, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Anisotropy, Female, Nuclear medicine, business, Diffusion MRI
الوصف: Background and Purpose Periventricular pseudocysts (PVPCs) are cystic cavities originating from the germinal matrix. The effects of PVPCs on the development of white matter (WM) in neonates remain unclear. This study aimed to characterise WM microstructural variations in neonates with PVPCs with and without additional abnormities on MRI. Materials and methods Neonates with PVPCs and controls with no MRI abnormalities were retrospectively enrolled. Test subjects were divided into groups 1 (isolated PVPCs) and 2 (PVPCs with additional MRI abnormalities). The PVPC MRI features collected included lateralisation, locularity, anatomic location, and the maximum anteroposterior diameter. Diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) were compared between the PVPC and control groups using tract-based spatial statistics. Results Thirty-eight neonates with PVPCs and 60 controls were enrolled. Groups 1 and 2 contained 15 and 23 subjects, respectively. The additional MRI findings in group 2 included intracranial haemorrhage, punctate WM lesions, hypoxic-ischaemic encephalopathy, and acute cerebral infarction. No significant differences were found in PVPC MRI features between the 2 test groups. Compared to controls, no significant changes in DTI metrics were observed in group 1 neonates; whereas extensive WM regions with decreased FA, increased RD, and unchanged/increased AD were found in group 2. Conclusions Isolated PVPCs are not independently correlated with WM microstructural variations in neonates. This result provides further evidence for supporting the benign outcome of fetuses with isolated PVPCs.
تدمد: 0720-048X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbec6544b45614148c4e94732e313fb2
https://doi.org/10.1016/j.ejrad.2019.05.005
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....bbec6544b45614148c4e94732e313fb2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0720048X