Diagnosis and Management of Group a Streptococcal Pharyngitis in the United States, 2011–2015
| العنوان: | Diagnosis and Management of Group a Streptococcal Pharyngitis in the United States, 2011–2015 |
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| المؤلفون: | Farnaz Vahidnia, Matthew Thompson, Yuan-Chi Lee, Joanna Sickler, Robert Luo, Bianca K. Frogner |
| المصدر: | BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Microbiological culture, Adolescent, medicine.drug_class, Streptococcus pyogenes, 030106 microbiology, Antibiotics, Immunologic Tests, Acute Pharyngitis, Streptococcal pharyngitis, Group A, Drug Prescriptions, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Internal medicine, Streptococcal Infections, Sore throat, Medicine, Humans, NAAT, lcsh:RC109-216, 030212 general & internal medicine, Child, Diagnostics, Retrospective Studies, business.industry, Incidence (epidemiology), Pharyngitis, United States, Anti-Bacterial Agents, Infectious Diseases, Practice Guidelines as Topic, Antibiotic use, Female, medicine.symptom, business, Nucleic Acid Amplification Techniques, Research Article |
| الوصف: | Background Clinical guidelines for the diagnosis of group A streptococcal (GAS) pharyngitis recommend the use of a rapid antigen detection test (RADT) and/or bacterial culture. This study evaluated the overall diagnosis and treatment of acute pharyngitis in the United States, including predictors of test type and antibiotic prescription. Methods A retrospective analysis of pharyngitis events from 2011 through 2015 was conducted using the MarketScan commercial/Medicare databases. A pharyngitis event was defined as occurring within 2 weeks from the index visit. Patient and provider characteristics were examined across 5 testing categories: RADT, RADT plus culture, other tests, nucleic acid amplification testing (NAAT), and no test. Multivariate models were used to identify significant predictors of NAAT use and antibiotic prescription. Results A total of 18.8 million acute pharyngitis events were identified in 11.6 million patients. Roughly two-thirds of events (68.2%) occurred once, and roughly a third of patients (29.1%) required additional follow-up, but hospitalization was rare (0.3%). Across all events, 43% were diagnosed by RADT, while 20% were diagnosed by RADT plus culture. The proportion of events diagnosed by NAAT increased 3.5-fold from 2011 to 2015 (0.06% vs 0.27%). Antibiotic use was frequent (49.3%), less often in combination with RADT plus culture (31.2%) or NAAT alone (34.5%) but significantly more often with RADT alone (53.4%) or no test (57.1%). Pediatricians were significantly less likely than other providers to prescribe antibiotics in their patients, regardless of patient age (p |
| اللغة: | English |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc107cfe8145ebac8ea9c3aeb7a2791e http://link.springer.com/article/10.1186/s12879-019-3835-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bc107cfe8145ebac8ea9c3aeb7a2791e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712334 |
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