Quantitative Measurement of Monocyte HLA-DR Expression in the Identification of Early-Onset Neonatal Infection
| العنوان: | Quantitative Measurement of Monocyte HLA-DR Expression in the Identification of Early-Onset Neonatal Infection |
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| المؤلفون: | Winnie C.W. Chu, Pak Cheung Ng, Raymond Pui On Wong, Kit Man Chui, Tai Fai Fok, Karen Li, Geng Li |
| المصدر: | Neonatology. 89:75-81 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neutrophils, Infections, Sensitivity and Specificity, Monocytes, Sepsis, Interquartile range, Streptococcal Infections, Pneumonia, Bacterial, medicine, Humans, Neonatology, Escherichia coli Infections, Receiver operating characteristic, business.industry, Monocyte, Receptors, IgG, Respiratory disease, Infant, Newborn, Phycoerythrin, HLA-DR Antigens, medicine.disease, Pneumonia, Neonatal infection, C-Reactive Protein, medicine.anatomical_structure, ROC Curve, Pediatrics, Perinatology and Child Health, Immunology, business, Biomarkers, Developmental Biology |
| الوصف: | Background: This study aimed to evaluate the diagnostic utilities of monocyte HLA-DR as an infection marker in the identification of early-onset clinical infection and pneumonia in newborn infants. Methods: Term newborns in whom infection was suspected when they were Results: A total of 288 infants with suspected sepsis were investigated, and 93 were found to be clinically infected. There were no significant differences in monocyte HLA-DR expression between the infected, non-infected and control groups at 0 h (median (interquartile range): 13,986 (10,994–18,544), 14,234 (12,045–17,474) and 18,441 (14,250–21,537) antibody phycoerythrin (PE) molecules bound/cell), and between infected and non-infected infants at 24 h (median (interquartile range): 17,772 (12,933–25,167) and 19,406 (14,885–24,225) antibody PE molecules bound/cell). The areas under the receiver operating characteristics (ROC) curves for HLA-DR, CD64 and CRP were 0.52–0.54, 0.88–0.94 and 0.75–0.77, respectively. We were unable to determine an optimal cutoff value for HLA-DR, as the diagnostic utilities of any cutoff point on the ROC curves were unable to satisfy the criteria (i.e. sensitivity and specificity ≧80%) for consideration as an useful diagnostic marker of infection. Conclusions: Our findings did not support the use of monocyte HLA-DR alone or in combination with other infection markers in the diagnosis of early-onset clinical infection and pneumonia in term newborns. |
| تدمد: | 1661-7819 1661-7800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7a60f63ec4216de3436c73692d2f1b https://doi.org/10.1159/000088288 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bc7a60f63ec4216de3436c73692d2f1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16617819 16617800 |
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