Urinary oxylipin signature as biomarkers to monitor the allograft function during the first six months post-renal transplantation
| العنوان: | Urinary oxylipin signature as biomarkers to monitor the allograft function during the first six months post-renal transplantation |
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| المؤلفون: | Valérie Bultel-Poncé, Ignacio De las Heras-Gómez, Angel Gil-Izquierdo, Thierry Durand, Federico Ferreres, Teresa Casas-Pina, Pedro Martínez-Hernández, Jean-Marie Galano, Luisa Jimeno, Santiago Llorente, Sonia Medina |
| المساهمون: | Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Hospital Univeristario Virgen de la Arrixaca, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Free Radical Biology and Medicine Free Radical Biology and Medicine, Elsevier, 2020, 146, pp.340-349. ⟨10.1016/j.freeradbiomed.2019.11.010⟩ |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Nephrology, medicine.medical_specialty, MESH: Oxylipins, Urinary system, [SDV]Life Sciences [q-bio], MESH: Allografts, Isoprostanes, Prostanoids, Urine, Biochemistry, Gastroenterology, MESH: Kidney Transplantation, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, Physiology (medical), Internal medicine, medicine, Humans, Oxylipins, chemistry.chemical_classification, Inflammation, Kidney, MESH: Humans, business.industry, MESH: Tandem Mass Spectrometry, Oxylipin, Allografts, Kidney Transplantation, 3. Good health, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Renal transplant, chemistry, Thromboxanes, Oxidative stress, Lipidomics, MESH: Biomarkers, business, 030217 neurology & neurosurgery, Biomarkers, Polyunsaturated fatty acid |
| الوصف: | International audience; Oxylipins such as isoprostanes (IsoPs), prostaglandins (PGs) and thromboxanes (TXs) are lipid mediators derived from the oxidation of polyunsaturated fatty acids, which regulate the magnitude of oxidative stress and inflammation processes and play an important role in pathophysiological processes in the kidney. A total of 36 oxylipins were analyzed by UHPLC-QqQ-MS/MS in the urine of 41 renal recipients from cadaveric donors of the Nephrology Unit of the University Hospital Virgen de la Arrixaca during the first six months after renal transplantation, in order to investigate several candidate oxylipins as more accurate and predictive biomarkers in renal transplantation than classical biological variables. A decrease in nine PGs, mostly from the AA-D pathway (p |
| تدمد: | 1873-4596 0891-5849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc889070e8135dcf6671ba7f71a368d8 https://pubmed.ncbi.nlm.nih.gov/31734358 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bc889070e8135dcf6671ba7f71a368d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18734596 08915849 |
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