The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
| العنوان: | The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type |
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| المؤلفون: | Gerald D. Silverberg, Thomas Saul, Stephen L. Huhn, Steven D. Chang, Helen Bronte-Stewart, Edward Rubenstein, Gary Heit, Katherine L. Possin, Richard A. Jaffe |
| المصدر: | Neurology. 57:1763-1766 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Urology, Neuropsychological Tests, Central nervous system disease, Lumbar, Cerebrospinal fluid, Alzheimer Disease, Reference Values, Humans, Medicine, Dementia, In patient, Dementia diagnosis, Aged, Cerebrospinal Fluid, Aged, 80 and over, business.industry, Parkinson Disease, Middle Aged, medicine.disease, Surgery, Reference values, Female, Neurology (clinical), Secretory Rate, business, Production rate |
| الوصف: | Objective: To evaluate the production rate of CSF in patients with differing disease states. Methods: The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 ± 4 years, mean ± SD), nine with PD over age 60 (aged 69 ± 6 years, mean ± SD), and seven with dementia of the Alzheimer’s type (AD) (aged 72 ± 9 years, mean ± SD). This method, based on the Masserman technique, employs ventricular rather than a lumbar access to the CSF space. Furthermore, the volume of CSF removed during the procedure is only 3 mL rather than 10 mL. Results: These measurements indicate that the mean rate of CSF production in patients with PD under age 60 was 0.47 ± 0.13 mL/minute, in patients with PD aged 60 or older the mean rate was 0.40 ± 0.12 mL/minute, and in patients with AD the mean rate was 0.20 ± 0.06 mL/minute. Conclusion: These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced. |
| تدمد: | 1526-632X 0028-3878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca39c9c792b199eb1c0fd58cf432fdb https://doi.org/10.1212/wnl.57.10.1763 |
| رقم الأكسشن: | edsair.doi.dedup.....bca39c9c792b199eb1c0fd58cf432fdb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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