Contrasting open-loop dynamic characteristics of sympathetic and vagal systems during baroreflex-mediated heart rate control in rats
| العنوان: | Contrasting open-loop dynamic characteristics of sympathetic and vagal systems during baroreflex-mediated heart rate control in rats |
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| المؤلفون: | Masaru Sugimachi, Kunihiko Tanaka, Takuya Nishikawa, Toru Kawada, Hiromi Yamamoto, Yohsuke Hayama |
| المصدر: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 317:R879-R890 |
| بيانات النشر: | American Physiological Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Sympathetic Nervous System, Baroreceptor, Physiology, Blood Pressure, 030204 cardiovascular system & hematology, Baroreflex, Models, Biological, Rats, Inbred WKY, Arc (geometry), 03 medical and health sciences, Neurons, Efferent, 0302 clinical medicine, Heart Rate, Physiology (medical), Internal medicine, Heart rate, medicine, Animals, Heart rate variability, business.industry, Vagus Nerve, Propranolol, Electric Stimulation, Rats, Cardiology, business, 030217 neurology & neurosurgery |
| الوصف: | Although heart rate (HR) is governed by the sympathetic and parasympathetic nervous systems, a head-to-head comparison of the open-loop dynamic characteristics of the total arc from a baroreceptor pressure input to the HR response has yet to be performed. We estimated the transfer function from carotid sinus pressure input to the HR response ( HCSP→HR) before and after bilateral vagotomy ( n = 7) as well as before and after the administration of a β-blocker propranolol ( n = 8) in anesthetized male Wistar-Kyoto rats. The carotid sinus pressure was perturbed according to a Gaussian white noise signal so that the input power spectra were relatively flat between 0.01 and 1 Hz. The gain plot of HCSP→HR was V-shaped. Vagotomy reduced the dynamic gain at 1 Hz (0.0598 ± 0.0065 to 0.0025 ± 0.0004 beats·min−1·mmHg−1, P < 0.001) but not at 0.01 or 0.1 Hz. β-Blockade reduced the dynamic gain at 0.01 Hz (0.247 ± 0.069 to 0.077 ± 0.017 beats·min−1·mmHg−1, P = 0.020) but not at 0.1 or 1 Hz. We also estimated the efferent limb transfer function from electrical vagal efferent stimulation to the HR response ( HVN→HR) under β-blockade conditions. We associated the model parameters of HVN→HR with the mean HR and the standard deviation of HR so that HVN→HR could be estimated based only on the HR data. We finally estimated the neural arc transfer function from a pressure input to efferent vagal nerve activity by dividing HCSP→HR by HVN→HR. The mathematically determined vagal neural arc showed derivative characteristics with its phase near zero radians at the lowest frequency. |
| تدمد: | 1522-1490 0363-6119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb66a275e4dddccd3773ff103647741 https://doi.org/10.1152/ajpregu.00231.2019 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bcb66a275e4dddccd3773ff103647741 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221490 03636119 |
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