التفاصيل البيبلوغرافية
| العنوان: |
Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes |
| المؤلفون: |
Joseph Swafford, S. Wamique Yusuf, Carla L. Warneke, Daniel J. Lenihan, Cheryl Hirch-Ginsburg, Mona Sarkiss, Nasser Lakkis, Gregory H. Botz, Jean-Bernard Durand, Andrew D. Shaw, J. Chris Champion |
| المصدر: |
Cancer. 109(3) |
| سنة النشر: |
2006 |
| مصطلحات موضوعية: |
Male, Cancer Research, Acute coronary syndrome, medicine.medical_specialty, Myocardial Infarction, Coronary Disease, Hemorrhage, Medical Records, symbols.namesake, Internal medicine, Neoplasms, Outcome Assessment, Health Care, Medicine, Humans, Myocardial infarction, Survival rate, Fisher's exact test, Aged, Retrospective Studies, Aspirin, business.industry, Platelet Count, Medical record, Anti-Inflammatory Agents, Non-Steroidal, Cancer, Retrospective cohort study, medicine.disease, Thrombocytopenia, Surgery, Survival Rate, Oncology, Acute Disease, symbols, Female, business, medicine.drug |
| الوصف: |
BACKGROUND. Patients with cancer who have thrombocytopenia may experience acute coronary syndromes (ACS), and the use of aspirin (ASA) poses an increased risk of bleeding. The purpose of this study was to test the hypothesis that the benefit of ASA therapy in the treatment of ACS would extend to cancer patients with thrombocytopenia and outweigh the risks of severe bleeding. METHODS. The records of all cancer patients diagnosed with an ACS in 2001 and referred for cardiology consultation were reviewed. Patients were divided into 2 groups on the basis of platelet count, >100 cells k/μL and ≤100 cells k/μL. Data were collected on the use of ASA therapy, bleeding complications, and survival rates. The authors assessed group differences by using the Wilcoxon rank sum test or 2-tailed Fisher exact test, as appropriate. Univariate and multivariate logistic regression models were used to assess factors potentially associated with 7-day survival. RESULTS. In cancer patients with ACS and thrombocytopenia, those who did not receive ASA had a 7-day survival rate of 6% compared with 90% in those who did receive ASA (P 100 cells k/μL) who received ASA had a 7-day survival rate of 88% compared with 45% in those who did not receive ASA (P = .0096). CONCLUSIONS. Therapy with ASA was associated with a significantly improved 7-day survival after ACS in cancer patients, with or without thrombocytopenia, and not associated with more severe bleeding. Cancer 2007;109:621–627. © 2006 American Cancer Society. |
| تدمد: |
0008-543X |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd786c60e6d328dd7ef16a2f7d61c618
https://pubmed.ncbi.nlm.nih.gov/17167763 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....bd786c60e6d328dd7ef16a2f7d61c618 |
| قاعدة البيانات: |
OpenAIRE |
