Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function
| العنوان: | Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function |
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| المؤلفون: | Ana Paula Duarte, Sara Correia, Ângelo Luís, Cátia V. Vaz, Lara R. S. Fonseca, Gonçalo R. Silva, Sílvia Socorro, Henrique J. Cardoso |
| المساهمون: | uBibliorum |
| المصدر: | Molecules, Vol 26, Iss 2941, p 2941 (2021) Fonseca, L R S, Silva, G R, Luís, Â, Cardoso, H J, Correia, S, Vaz, C V, Duarte, A P & Socorro, S 2021, ' Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function ', Molecules, vol. 26, no. 10, 2941 . https://doi.org/10.3390/molecules26102941 Molecules Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | sweet cherries, Cell Survival, proliferation, Metabolic reprogramming, Phytochemicals, Pharmaceutical Science, Organic chemistry, Context (language use), Review, Biology, Prunus avium, Carcinogenic process, Analytical Chemistry, 03 medical and health sciences, Prunus, metastization, 0302 clinical medicine, QD241-441, SDG 3 - Good Health and Well-being, Drug Discovery, medicine, Humans, metabolic reprogramming, oxidative stress, Food science, Physical and Theoretical Chemistry, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Sweet Cherries, apoptosis, Cancer, food and beverages, anti-cancer agents, medicine.disease, invasion, Antineoplastic Agents, Phytogenic, anthocyanins, Bioavailability, Chemistry (miscellaneous), inflammation, 030220 oncology & carcinogenesis, Dietary Supplements, Molecular Medicine, Function (biology) |
| الوصف: | Sweet cherries (Prunus avium L.) are among the most appreciated fruits worldwide because of their organoleptic properties and nutritional value. The accurate phytochemical composition and nutritional value of sweet cherries depends on the climatic region, cultivar, and bioaccessibility and bioavailability of specific compounds. Nevertheless, sweet cherry extracts are highly enriched in several phenolic compounds with relevant bioactivity. Over the years, technological advances in chemical analysis and fields as varied as proteomics, genomics and bioinformatics, have allowed the detailed characterization of the sweet cherry bioactive phytonutrients and their biological function. In this context, the effect of sweet cherries on suppressing important events in the carcinogenic process, such as oxidative stress and inflammation, was widely documented. Interestingly, results from our research group and others have widened the action of sweet cherries to many hallmarks of cancer, namely metabolic reprogramming. The present review discusses the anticarcinogenic potential of sweet cherries by addressing their phytochemical composition, the bioaccessibility and bioavailability of specific bioactive compounds, and the existing knowledge concerning the effects against oxidative stress, chronic inflammation, deregulated cell proliferation and apoptosis, invasion and metastization, and metabolic alterations. Globally, this review highlights the prospective use of sweet cherries as a dietary supplement or in cancer treatment. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7c1b6c830eb0c0740ef0e11cbe0cb8 https://www.mdpi.com/1420-3049/26/10/2941 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bd7c1b6c830eb0c0740ef0e11cbe0cb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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