Prenatal lipopolysaccharide exposure affects sexual dimorphism in different germlines of mice with a depressive phenotype
| العنوان: | Prenatal lipopolysaccharide exposure affects sexual dimorphism in different germlines of mice with a depressive phenotype |
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| المؤلفون: | Mariana Sayuri Berto Udo, Elizabeth Teodorov, Daniel Wagner Hamada Cohn, Maria Martha Bernardi, Thiago Marinho Reis-Silva, Thaísa Meira Sandini |
| المساهمون: | Universidade de São Paulo (USP), Universidade Federal do ABC (UFABC), Universidade Estadual Paulista (Unesp) |
| المصدر: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, medicine.medical_specialty, Offspring, Lipopolysaccharide, Biology, Motor Activity, General Biochemistry, Genetics and Molecular Biology, Open field, Pharmacology, Toxicology and Pharmaceutics(all), 03 medical and health sciences, Mice, 0302 clinical medicine, Endotoxin, Pregnancy, Internal medicine, parasitic diseases, medicine, Prenatal, Animals, General Pharmacology, Toxicology and Pharmaceutics, Sex Characteristics, Biochemistry, Genetics and Molecular Biology(all), Depression, Tail suspension test, General Medicine, medicine.disease, Phenotype, Generations, 030227 psychiatry, Sexual dimorphism, Adult Stem Cells, Endocrinology, Prenatal Exposure Delayed Effects, Gestation, Female, 030217 neurology & neurosurgery, Sex characteristics |
| الوصف: | Made available in DSpace on 2018-11-26T15:28:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-15 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Programa Individual de pesquisa para docentes da Universidade Paulista Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The objective of the present study was to investigate whether prenatal lipopolysaccharide (LPS) administration modifies the expression of depressive and non-depressive-like behavior inmale and female mice across two generations. The sexual dimorphism of these mice was also examined in the open-field test. Male and female mice of the parental (F0) generation were selected for depressive-or non-depressive-like behavioral profiles using the tail suspension test (TST). Animals with similar profiles were matched for further mating. On gestation day (GD) 15, pregnant F0 mice received LPS (100 mu g/kg, i.p.) and were allowed to nurture their offspring freely. Adult male and female of the F1 generation were then selected according to behavioral profiles and observed in the open field. Male and female mice of the two behavioral profiles were then mated to obtain the F2 generation. Adults from the F2 generation were also behaviorally phenotyped, and open field behavior was assessed. Male mice that were selected for depressive-and non-depressive-like behaviors and treated or not with LPS in the parental generation exhibited similar proportions of behavioral profiles in both filial lines, but LPS exposure increased the number of depressive-like behavior. An effect of gender was observed in the F1 and F2 generations, in which male mice were more sensitive to the intergenerational effects of LPS in the TST. These data indicate that prenatal LPS exposure on GD15 in the F0 generation influenced the transmission of depressive-and nondepressive-like behavior across filial lines, with sexual dimorphism between phenotypes. (C) 2016 Elsevier Inc. All rights reserved. Univ Sao Paulo, Dept Neurosci & Behav, Inst Psychol, BR-05508 Sao Paulo, Brazil Univ Sao Paulo, Sch Vet Med, Neuroimmunomodulat Res Grp, BR-05508 Sao Paulo, Brazil Univ Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508 Sao Paulo, Brazil Fed Univ ABC, Math Computat & Cognit Ctr, Santo andre, Brazil Univ Estadual Paulista, Postgrad Program Environm & Expt Pathol, Sao Paulo, Brazil Univ Estadual Paulista, Postgrad Program Dent, Sao Paulo, Brazil Univ Estadual Paulista, Postgrad Program Environm & Expt Pathol, Sao Paulo, Brazil Univ Estadual Paulista, Postgrad Program Dent, Sao Paulo, Brazil Programa Individual de pesquisa para docentes da Universidade Paulista: UNIP-7-02915-2014 FAPESP: 2013/03912-0 FAPESP: 09/51886-3 |
| تدمد: | 1879-0631 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8471f25c24cca79fa6ae2877a3e898 https://pubmed.ncbi.nlm.nih.gov/26898128 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bd8471f25c24cca79fa6ae2877a3e898 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790631 |
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