Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces
| العنوان: | Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces |
|---|---|
| المؤلفون: | Yuliya Nashchekina, Tatiana B. Tennikova, Antonina Lavrentieva, Thomas Scheper, Evgenia Korzhikova-Vlakh, Viktor Korzhikov-Vlakh, Ivan Guryanov, Ilia Averianov, Lukas Raddatz, D. S. Polyakov, Ekaterina Sinitsyna |
| المصدر: | Polymers 10 (2018), Nr. 12 Polymers Volume 10 Issue 12 Polymers, Vol 10, Iss 12, p 1299 (2018) |
| بيانات النشر: | Basel : MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie, Polymers and Plastics, Biocompatibility, Polyesters, Antigen-antibody reactions, Biomimetic materials, Nanoparticle, 02 engineering and technology, Biofunctionalization, 010402 general chemistry, 01 natural sciences, Article, Bone tissue engineering, lcsh:QD241-441, lcsh:Organic chemistry, Phagocytosis, Biomimetics, Polyvinylsaccharide, Scaffolds (biology), Bone, Hydrophilicity, Controlled drug delivery, chemistry.chemical_classification, Targeted drug delivery, Bioligands, Tissue, Cell engineering, Scaffolds for bone tissue engineering, Cell adhesion, General Chemistry, Polymer, Cells adhesion, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Polyester, Chemical engineering, chemistry, Covalent bond, PCL, ddc:540, Drug delivery, Nanoparticles for drug delivery, Surface modification, PLA, Nanoparticles, 0210 nano-technology, Peptides |
| الوصف: | To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(&epsilon caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (&ldquo self-peptide&rdquo or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.15488/4297 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda0e835be829eaf42d3f9f8c9f5a271 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bda0e835be829eaf42d3f9f8c9f5a271 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.15488/4297 |
|---|