High-Grade Serous Ovarian Cancer: Associations between BRCA Mutation Status, CT Imaging Phenotypes, and Clinical Outcomes
| العنوان: | High-Grade Serous Ovarian Cancer: Associations between BRCA Mutation Status, CT Imaging Phenotypes, and Clinical Outcomes |
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| المؤلفون: | Debra A. Goldman, Angela G. Arnold, Robert A. Soslow, Evis Sala, Melvin D'Anastasi, Mithat Gonen, Hedvig Hricak, Sarah A. Johnson, Stephanie Nougaret, Yulia Lakhman, Ramon E. Sosa, Hebert Alberto Vargas, Noah D. Kauff, Maura Miccò, Krishna Juluru |
| المساهمون: | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Memorial Sloane Kettering Cancer Center [New York], University of Medicine and Pharmacy, Luliu-Hatieganu, Department of Medicine, Memorial Sloane Kettering Cancer Center [New York]-Weill Medical College of Cornell University [New York] |
| المصدر: | Radiology Radiology, Radiological Society of North America, 2017, 285 (2), pp.472-481. ⟨10.1148/radiol.2017161697⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, Adult, medicine.medical_specialty, animal structures, endocrine system diseases, Genes, BRCA2, Genes, BRCA1, [SDV.CAN]Life Sciences [q-bio]/Cancer, Logistic regression, Lesser sac, Disease-Free Survival, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, skin and connective tissue diseases, Original Research, Aged, Retrospective Studies, Aged, 80 and over, Ovarian Neoplasms, Univariate analysis, business.industry, Hazard ratio, BRCA mutation, Retrospective cohort study, Odds ratio, Middle Aged, Debulking, female genital diseases and pregnancy complications, 3. Good health, medicine.anatomical_structure, Phenotype, MESH: Aged, 80 and over, Gene BRCA1, Gene BRCA2, Mutation/genetics, 030220 oncology & carcinogenesis, Mutation, Female, business, Tomography, X-Ray Computed |
| الوصف: | International audience; Purpose To investigate the associations between BRCA mutation status and computed tomography (CT) phenotypes of high-grade serous ovarian cancer (HGSOC) and to evaluate CT indicators of cytoreductive outcome and survival in patients with BRCA-mutant HGSOC and those with BRCA wild-type HGSOC. Materials and Methods This HIPAA-compliant, institutional review board-approved retrospective study included 108 patients (33 with BRCA mutant and 75 with BRCA wild-type HGSOC) who underwent CT before primary debulking. Two radiologists independently reviewed the CT findings for various qualitative CT features. Associations between CT features, BRCA mutation status, cytoreductive outcome, and progression-free survival (PFS) were evaluated by using logistic regression and Cox proportional hazards regression, respectively. Results Peritoneal disease (PD) pattern, presence of PD in gastrohepatic ligament, mesenteric involvement, and supradiaphragmatic lymphadenopathy at CT were associated with BRCA mutation status (multiple regression: P < .001 for each CT feature). While clinical and CT features were not associated with cytoreductive outcome for patients with BRCA-mutant HGSOC, presence of PD in lesser sac (odds ratio [OR] = 2.40) and left upper quadrant (OR = 1.19), mesenteric involvement (OR = 7.10), and lymphadenopathy in supradiaphragmatic (OR = 2.83) and suprarenal para-aortic (OR = 4.79) regions were associated with higher odds of incomplete cytoreduction in BRCA wild-type HGSOC (multiple regression: P < .001 each CT feature). Mesenteric involvement at CT was associated with significantly shorter PFS for both patients with BRCA-mutant HGSOC (multiple regression: hazard ratio [HR] = 26.7 P < .001) and those with BRCA wild-type HGSOC (univariate analysis: reader 1, HR = 2.42, P < .001; reader 2, HR = 2.61; P < .001). Conclusion Qualitative CT features differed between patients with BRCA-mutant HGSOC and patients with BRCA wild-type HGSOC. CT indicators of cytoreductive outcome varied according to BRCA mutation status. Mesenteric involvement at CT was an indicator of significantly shorter PFS for both patients with BRCA-mutant HGSOC and those with BRCA wild-type HGSOC. © RSNA, 2017 Online supplemental material is available for this article. |
| اللغة: | English |
| تدمد: | 0033-8419 1527-1315 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd7bb830742d5f3c647295df490f845 https://hal.umontpellier.fr/hal-02313889 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bdd7bb830742d5f3c647295df490f845 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00338419 15271315 |
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