Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States: A report from the SEUS Study Group
| العنوان: | Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States: A report from the SEUS Study Group |
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| المؤلفون: | Morgan Walker, George E. Nelson, Athena L V Hobbs, Salil Goorha, Nicholas A Turner, Christina T. Fiske, Priyenka Thapa, Ronald M Beaulieu, Steven S Spires, Jeffrey Wright, John W. Gnann, Muhammad Sheikh, Imad Omer, Ryan K Dare |
| المصدر: | Infection Control and Hospital Epidemiology |
| بيانات النشر: | Cambridge University Press (CUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Microbiology (medical), medicine.medical_specialty, Multivariate analysis, Epidemiology, medicine.medical_treatment, MEDLINE, Disease, law.invention, Risk Factors, law, Internal medicine, medicine, Humans, Hospital Mortality, Retrospective Studies, Mechanical ventilation, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, Odds ratio, Intensive care unit, United States, Confidence interval, Hospitalization, Intensive Care Units, Infectious Diseases, Original Article, business |
| الوصف: | Objective:Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients in the Southeast region of the United States.Design, setting, and participants:Multicenter, retrospective cohort including 502 adults hospitalized with laboratory-confirmed COVID-19 between March 1, 2020, and May 8, 2020 within 1 of 15 participating hospitals in 5 health systems across 5 states in the Southeast United States.Methods:The study objectives were to identify risk factors that could increase progression to hospital mortality and severe disease (defined as a composite of intensive care unit admission or requirement of mechanical ventilation) in hospitalized SARS-CoV-2 patients in the Southeast United States.Results:In total, 502 patients were included, and 476 of 502 (95%) had clinically evaluable outcomes. The hospital mortality rate was 16% (76 of 476); 35% (177 of 502) required ICU admission and 18% (91 of 502) required mechanical ventilation. By both univariate and adjusted multivariate analyses, hospital mortality was independently associated with age (adjusted odds ratio [aOR], 2.03 for each decade increase; 95% confidence interval [CI], 1.56-–2.69), male sex (aOR, 2.44; 95% CI, 1.34–4.59), and cardiovascular disease (aOR, 2.16; 95% CI, 1.15–4.09). As with mortality, risk of severe disease was independently associated with age (aOR, 1.17 for each decade increase; 95% CI, 1.00–1.37), male sex (aOR, 2.34; 95% CI, 1.54–3.60), and cardiovascular disease (aOR, 1.77; 95% CI, 1.09–2.85).Conclusions:In an adjusted multivariate analysis, advanced age, male sex, and cardiovascular disease increased risk of severe disease and mortality in patients with COVID-19 in the Southeast United States. In-hospital mortality risk doubled with each subsequent decade of life. |
| تدمد: | 1559-6834 0899-823X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdda513da7babed06ad245a2eba26d2e https://doi.org/10.1017/ice.2020.1435 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bdda513da7babed06ad245a2eba26d2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15596834 0899823X |
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