Incidence of non-Hodgkin's lymphoma among individuals with chronic hepatitis B virus infection
| العنوان: | Incidence of non-Hodgkin's lymphoma among individuals with chronic hepatitis B virus infection |
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| المؤلفون: | Cary Caldwell, Uchenna H. Iloeje, Jun Shan, Karen Wells, Marianne Ulcickas Yood, L. Sanders, Charles P. Quesenberry, Mary Lou Skovron, Dianlin Guo, M. Michele Manos |
| المصدر: | Hepatology. 46:107-112 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Population, medicine.disease_cause, Cohort Studies, Hepatitis B, Chronic, Orthohepadnavirus, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, education, Hepatitis B virus, education.field_of_study, Hepatology, biology, Proportional hazards model, business.industry, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), Liver Neoplasms, Hazard ratio, Reproducibility of Results, virus diseases, Middle Aged, medicine.disease, biology.organism_classification, United States, Non-Hodgkin's lymphoma, Cohort, Immunology, Female, business |
| الوصف: | Although hepatitis C virus (HCV) infection has been shown to be associated with development of non-Hodgkin's lymphoma (NHL), few studies have investigated the association between chronic HBV infection and NHL. The purpose of this study was to compare the incidence of NHL between patients with and without chronic hepatitis B virus (HBV) infection. Using automated laboratory result and clinical data from two United States health systems, we identified individuals with chronic HBV infection from January 1, 1995 through December 31, 2001. Using each health system's population-based tumor registry, we identified all cases of NHL diagnosed through December 31, 2002. We excluded any individual with a history of NHL or human immunodeficiency virus (HIV). We fit Cox proportional hazards models to calculate hazard ratios comparing the incidence of NHL between chronic HBV-infected patients (N = 3,888) and patients without HBV (N = 205,203) drawn from the source populations. We identified 8 NHL cases in the chronic HBV infection cohort and 111 cases in the comparison cohort. Patients with chronic HBV infection were 2.8 times more likely to develop NHL than matched comparison patients (adjusted hazard ratio = 2.80, 95% confidence interval = 1.16-6.75), after controlling for age, race, sex, income, Charlson comorbidity index, study site, and HCV infection. Conclusion: chronic HBV-infected patients were nearly 3 times more likely to develop NHL than comparison patients. (HEPATOLOGY 2007.) |
| تدمد: | 1527-3350 0270-9139 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddcf93180fb0c4304a71d4989a9bf8d https://doi.org/10.1002/hep.21642 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bddcf93180fb0c4304a71d4989a9bf8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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