Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance
| العنوان: | Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance |
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| المؤلفون: | Jian-Yu Zhu, Wen-Li Mi, Wei Yang, Feng Hai, Xue-Ming Hu, Qi-Liang Mao-Ying, Li-Xia Du, Yu Chen, Meng-Ting Zhang, Jia-He Tian, Yu-Xia Chu, Yan-Qing Wang, Hong Zhou, Shen-Bin Liu |
| المصدر: | Science Signaling. 14 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Moderate to severe, Analgesic, macromolecular substances, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Animals, Medicine, In patient, Molecular Biology, Morphine, business.industry, Receptors, Interleukin-1, Cell Biology, Interleukin-33, Spinal cord, Rats, Interleukin 33, medicine.anatomical_structure, Spinal Cord, Hyperalgesia, medicine.symptom, business, medicine.drug |
| الوصف: | Morphine and other opiates are highly effective for treating moderate to severe pain. However, morphine-induced hyperalgesia and analgesic tolerance prevent durable efficacy in patients. Here, we investigated the underlying molecular mechanisms of this phenomenon. We found that repeated subcutaneous injections of morphine in mice increased the abundance of the cytokine interleukin-33 (IL-33) primarily in oligodendrocytes and astrocytes and that of its receptor ST2 mainly in astrocytes. Pharmacological inhibition or knockdown of IL-33 or ST2 in the spinal cord attenuated morphine-induced hyperalgesia and analgesic tolerance in mice, as did global knockout of either |
| تدمد: | 1937-9145 1945-0877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde45c9a2f07e20a9835426ce1250f9b https://doi.org/10.1126/scisignal.abe3773 |
| رقم الأكسشن: | edsair.doi.dedup.....bde45c9a2f07e20a9835426ce1250f9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19379145 19450877 |
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