Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma
| العنوان: | Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma |
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| المؤلفون: | Xin Zhou, Feng Gao, Meng‑Nan Shao, Xi‑Wen Liao, Ling Yan, Li‑Cheng Zhu, Xiang‑Kun Wang, Hai‑Lun Xie, Jia‑Liang Gan, Yi‑Zhen Gong, Quan‑Fa Han, Guo‑Tian Ruan |
| المصدر: | Oncology Letters |
| بيانات النشر: | Spandidos Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, biology, Oncogene, diagnosis, Angiogenesis, mRNA, Articles, 03 medical and health sciences, γ-aminobutyric acid type A receptor, 030104 developmental biology, 0302 clinical medicine, colon adenocarcinoma, Oncology, Cell-matrix adhesion, 030220 oncology & carcinogenesis, biology.protein, Cancer research, GABRA3, GABRD, prognosis, KEGG, GABRG3, Integrin binding |
| الوصف: | In the present study, the significance of GABAA genes in colon adenocarcinoma (COAD) were investigated from the view of diagnosis and prognosis. All data were achieved from The Cancer Genome Atlas. Overall survival was analyzed by the Kaplan-Meier analyses and Cox regression model and the hazard ratios and 95% confidence interval were calculated for computation. The Database for Annotation, Visualization and Integrated Discovery, and the Biological Networks Gene Ontology (BiNGO) softwares were applied to assess the biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway analysis to predict the biological function of GABAA genes. The associated Gene Ontology and KEGG pathways were conducted by Gene Set Enrichment Analysis (GSEA). From receiver operating characteristics curves analysis, it was found that the expression of GABR, γ-aminobutyric acid type A receptor GABRA2, GABRA3, GABRB2, GABRB3, GABRG2, GABRG3, GABRD, GABRE were correlated with COAD occurrence [P0.7]. The low expression of the GABRB1, GABRD, GABRP and GABRQ in genes after tumor staging adjustment were positively correlated with the overall survival rate [P=0.049, hazard ratio (HR)=1.517, 95% confidence interval (CI)=1.001–2.297; P=0.006, HR=1.807, 95% CI=1.180–2.765; P=0.005, HR=1.833, 95% CI=1.196–2.810; P=0.034, HR=1.578, 95% CI=1.036–2.405). GSEA showed enrichment of cell matrix adhesion, integrin binding, angiogenesis, endothelial growth factor and endothelial migration regulation in patients with COAD with GABRD overexpression. GABRB1, GABRD, GABRP and GABRQ were associated with the prognostic factors of COAD. The expression levels of GABRA2, GABRA3, GABRB2, GABRB3, GABRG2, GABRD and GABRE may allow differentiation between tumor tissues and adjacent normal tissues. |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdea415f97f50fb680765ad15adeb458 https://doi.org/10.3892/ol.2020.11573 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bdea415f97f50fb680765ad15adeb458 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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