The effect of phthalates exposure during pregnancy on asthma in infants aged 0 to 36 months: a birth cohort study
| العنوان: | The effect of phthalates exposure during pregnancy on asthma in infants aged 0 to 36 months: a birth cohort study |
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| المؤلفون: | Jian-Qing, Wang, Chun-Mei, Liang, Ya-Bin, Hu, Xun, Xia, Zhi-Juan, Li, Hui, Gao, Jie, Sheng, Kun, Huang, Su-Fang, Wang, Peng, Zhu, Jia-Hu, Hao, Fang-Biao, Tao |
| المصدر: | Environmental Geochemistry and Health. 45:1951-1974 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Environmental Engineering, Geochemistry and Petrology, Environmental Chemistry, General Medicine, General Environmental Science, Water Science and Technology |
| الوصف: | This cohort study sought to investigate the effects of phthalates exposure during pregnancy on offspring asthma and its association with placental stress and inflammatory factor mRNA expression levels. A total of 3474 pregnant women from the China Ma'anshan birth cohort participated in this study. Seven phthalate metabolites were detected in urine samples during pregnancy by solid phase extraction-high-performance liquid chromatography tandem mass spectrometry. Placenta stress and inflammation mRNA expression were assessed by real-time quantitative polymerase chain reaction (RT-qPCR). Early pregnancy may be the critical period when phthalates exposure increases the risk of asthma in infants and young children, and there is a certain gender difference in the risk of asthma in infants and young children. Moreover, through the placenta stress and inflammatory factor associated with infant asthma found anti-inflammatory factor of interleukin-10 (IL-10) mRNA expression will reduce the risk of 36-month-old male infant asthma. The expression of interleukin-4(IL-4) and macrophage (M2) biomarker cluster of differentiation 206(CD206) mRNA reduced the risk of asthma in 18-month-old female infants. Placental stress and inflammatory response were analyzed using mediating effects. Tumor necrosis factor-α (TNFα) showed a complete mediating effect between mono-benzyl phthalate (MBzP) exposure in early pregnancy and asthma in 12-month-old males, and IL-10 also showed a complete mediating effect between mono-n-butyl phthalate (MBP) exposure in early and late pregnancy and asthma in 36-month-old males. In summary, exposure to phthalates during pregnancy may contribute to the development of asthma in infants, which may be associated with placental stress and inflammation. |
| تدمد: | 1573-2983 0269-4042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5248a9e7580a5b85f4fc76f3e928f4 https://doi.org/10.1007/s10653-022-01320-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....be5248a9e7580a5b85f4fc76f3e928f4 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732983 02694042 |
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