An unusual hematopoietic stem cell transplantation for donor acute lymphoblastic leukemia: a case report
| العنوان: | An unusual hematopoietic stem cell transplantation for donor acute lymphoblastic leukemia: a case report |
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| المؤلفون: | Yonggong Yang, Yipeng Ling, Suning Chen, Di Zhou, Bing Chen, Jian Ouyang, Yueyi Xu, Ting Xie |
| المصدر: | BMC Cancer BMC Cancer, Vol 20, Iss 1, Pp 1-5 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_treatment, Case Report, Hematopoietic stem cell transplantation, Acute lymphoblastic leukemia, lcsh:RC254-282, CD19, BRAF, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, hemic and lymphatic diseases, Exome Sequencing, Genetics, medicine, Humans, Transplantation, Homologous, Exome sequencing, Bone Marrow Transplantation, biology, business.industry, SF3B1, Hematopoietic Stem Cell Transplantation, Donor leukemia, Anemia, Aplastic, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Phosphoproteins, Tissue Donors, Haematopoiesis, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunology, Mutation, biology.protein, Female, Bone marrow, RNA Splicing Factors, Stem cell, business |
| الوصف: | Background Donor acute lymphoblastic leukemia with recipient intact is a rare condition. We report a case of donor developing acute lymphoblastic leukemia 8 yrs after donating both bone marrow and peripheral blood hematopoietic stem cells. Case presentation This case report describes a 51-year old female diagnosed with acute lymphoblastic leukemia who donated both bone marrow and peripheral blood stem cells 8 yrs ago for her brother with severe aplastic anemia. Whole exome sequencing revealed leukemic genetic lesions (SF3B1 and BRAF mutation) only appeared in the donor sister, not the recipient, and an unusual type of hematopoietic stem cell transplantation with the recipient’s peripheral blood stem cells was done. The patient remained in remission for 3 months before disease relapsed. CD19 CAR-T therapy followed by HLA-identical unrelated hematopoietic stem cell transplantation was applied and the patient remains in remission for 7 months till now. Conclusions This donor leukemia report supports the hypothesis that genetic lesions happen randomly in leukemogenesis. SF3B1 combined with BRAF mutation might contribute to the development of acute lymphoblastic leukemia. |
| اللغة: | English |
| تدمد: | 1471-2407 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b5b957cbda4240d2c3c63e9b5ba67 http://europepmc.org/articles/PMC7060641 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....be5b5b957cbda4240d2c3c63e9b5ba67 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712407 |
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