Serum thrombospondin-1 serves as a novel biomarker and agonist of gemcitabine-based chemotherapy in intrahepatic cholangiocarcinoma

التفاصيل البيبلوغرافية
العنوان: Serum thrombospondin-1 serves as a novel biomarker and agonist of gemcitabine-based chemotherapy in intrahepatic cholangiocarcinoma
المؤلفون: Dong-yang Ding, Xiao-jie Gan, Jia-ning Zhang, Guo-jun Hou, Qi-fei Tao, Da-peng Sun, Wen Li, Yuan Yang, Wen-bin Ding, Jian Yu, Lei Liu, Fu Yang, Wei-ping Zhou, Sheng-xian Yuan
المصدر: British journal of cancer.
سنة النشر: 2022
مصطلحات موضوعية: Cancer Research, Oncology
الوصف: At present, the first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC) is gemcitabine combined with cisplatin, but a considerable portion of ICC patients exhibit resistance to gemcitabine. Therefore, finding sensitisers for gemcitabine chemotherapy in ICC patients and predicting molecular markers for chemotherapy efficacy have become urgent needs.In this study, PDX models were established to conduct gemcitabine susceptibility tests. The selected PDX tissues of the chemotherapy-sensitive group and drug-resistant group were subjected to transcriptome sequencing and protein chip technology to identify the key genes. Sixty-one ICC patients treated with gemcitabine chemotherapy were recruited for clinical follow-up validation.We found that thrombospondin-1 (TSP1) can predict gemcitabine chemosensitivity in ICC patients. The expression level of TSP1 could reflect the sensitivity of ICC patients to gemcitabine chemotherapy. Functional experiments further confirmed that TSP1 can increase the efficacy of gemcitabine chemotherapy for ICC. A mechanism study showed that TSP1 may affect the intake of oleic acid by binding to the CD36 receptor.In summary, we found a key molecule-TSP1-that can predict and improve the sensitivity of ICC patients to gemcitabine chemotherapy, which is of great significance for the treatment of advanced cholangiocarcinoma.
تدمد: 1532-1827
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be661249903cc39cc57de2d5485256c2
https://pubmed.ncbi.nlm.nih.gov/36526676
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....be661249903cc39cc57de2d5485256c2
قاعدة البيانات: OpenAIRE