Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking
| العنوان: | Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking |
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| المؤلفون: | Sonja, Kuth, Emine, Karakaya, Nina, Reiter, Laura, Schmidt, Friedrich, Paulsen, Jörg, Teßmar, Silvia, Budday, Aldo R, Boccaccini |
| المصدر: | Tissue Engineering Part C: Methods. 28:301-313 |
| بيانات النشر: | Mary Ann Liebert Inc, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Mice, Tissue Engineering, Tissue Scaffolds, Biomedical Engineering, Animals, Gelatin, Humans, Medicine (miscellaneous), Hydrogels, Bioengineering, Fibroblasts, Hyaluronic Acid |
| الوصف: | Hydrogels are ideal materials for mimicking and engineering soft tissue. Hyaluronic acid is a linear polysaccharide native to the human extracellular matrix. In this study, we first develop and characterize two hydrogel compositions built from oxidized HA and gelatin with and without alginate-di-aldehyde (ADA) crosslinked by ionic and enzymatic agents with potential applications in soft tissue engineering and tissue mimicking structures. The stability under incubation conditions was improved by adjusting crosslinking times. Through large-strain mechanical measurements, the hydrogels' properties were compared to human brain tissue and the samples containing ADA revealed similar mechanical properties to the native tissue specimens in cyclic compression-tension. |
| تدمد: | 1937-3392 1937-3384 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8fc01d4379d18ebb78b220f4c97c59 https://doi.org/10.1089/ten.tec.2022.0004 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....be8fc01d4379d18ebb78b220f4c97c59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19373392 19373384 |
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