Clinical implications of bronchoscopy for immune checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer
| العنوان: | Clinical implications of bronchoscopy for immune checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer |
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| المؤلفون: | Osamu Nishiyama, Hidetoshi Hayashi, Akiko Sano, Yuji Tohda, Yusaku Nishikawa, Takashi Oomori, Kazuhiko Nakagawa, Shigeki Shimizu, Ryo Yamazaki, Kosuke Isomoto, Koji Haratani, Junko Tanizaki |
| المصدر: | BMC Pulmonary Medicine BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Bronchoalveolar lavage, Male, medicine.medical_specialty, Lung Neoplasms, Biopsy, Lung biopsy, Lung injury, Gastroenterology, Diseases of the respiratory system, 03 medical and health sciences, 0302 clinical medicine, Bronchoscopy, Fibrosis, Internal medicine, Carcinoma, Non-Small-Cell Lung, medicine, Alveolitis, Humans, Clinical significance, Lung cancer, Immune Checkpoint Inhibitors, Lung, Pneumonitis, Organizing pneumonia, Aged, Retrospective Studies, RC705-779, medicine.diagnostic_test, business.industry, Research, Pneumonia, respiratory system, Middle Aged, medicine.disease, respiratory tract diseases, 030228 respiratory system, 030220 oncology & carcinogenesis, Lymphocyte, Female, business, Bronchoalveolar Lavage Fluid |
| الوصف: | Background The utility of bronchoscopy for patients with suspected immune checkpoint inhibitor (ICI)-related pneumonitis is currently debatable. The purpose of this study was to examine the findings of bronchoalveolar lavage (BAL) analysis and transbronchial lung biopsy (TBLB) in non-small cell lung cancer (NSCLC) patients with ICI-related pneumonitis, and to elucidate the clinical significance of bronchoscopy for this health condition. Patients and methods Consecutive NSCLC patients treated with ICIs, diagnosed with ICI-related pneumonitis after undergoing bronchoscopy between October 2015 and March 2019 were retrospectively screened. Findings of BAL fluid analysis and/or TBLB specimen histology were reviewed. Results Twelve patients underwent bronchoscopy for the diagnosis of ICI-related pneumonitis, ten of whom underwent BAL. An increase in the proportion of lymphocytes higher than 20% was observed in all ten patients. An increase in the proportion of neutrophils (> 10%) and eosinophils (> 10%) was observed in two and one patient, respectively. TBLB specimens were analyzed for eight patients. Major histologic findings included alveolitis in seven (87.5%) and organizing pneumonia (OP) in five (62.5%) patients. Other findings included acute lung injury and fibrosis. All twelve patients demonstrated favorable outcomes. Conclusion A major characteristic of BAL analysis in ICI-related pneumonitis with NSCLC was an increased proportion of lymphocytes. The histologic features of lung tissue included alveolitis and/or OP. Acute lung injury and fibrosis were observed. Although the necessity of bronchoscopy should be determined on a case-by-case basis, it is necessary to assess these parameters when proper differential diagnosis is needed. |
| اللغة: | English |
| تدمد: | 1471-2466 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea79ee1e012566e3bf874b022801e0d http://europepmc.org/articles/PMC8106835 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bea79ee1e012566e3bf874b022801e0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712466 |
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