Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
| العنوان: | Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice |
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| المؤلفون: | Amaia Rodríguez, Sara Becerril, Victoria Catalán, Beatriz Ramírez, Neira Sáinz, Gema Frühbeck, Javier Gómez-Ambrosi |
| المصدر: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname PLoS ONE, Vol 4, Iss 9, p e6808 (2009) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Leptin, medicine.medical_specialty, lcsh:Medicine, Myostatin, Protein degradation, Biology, Physiology/Muscle and Connective Tissue, Muscle hypertrophy, Diabetes and Endocrinology/Obesity, Muscles/pathology, Mice, Troponin T, Proliferating Cell Nuclear Antigen, Internal medicine, medicine, Animals, Cyclin D1, FoxO3 protein, mouse, lcsh:Science, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Soleus muscle, Multidisciplinary, Physiology/Endocrinology, Troponin T/biosynthesis, Muscles, Gene Expression Profiling, Muscle cell proliferation, Forkhead Box Protein O3, lcsh:R, Forkhead Transcription Factors, musculoskeletal system, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Muscle atrophy, Mice, Inbred C57BL, Endocrinology, Trans-Activators, biology.protein, lcsh:Q, medicine.symptom, Myofibril, Research Article, Transcription Factors |
| الوصف: | Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as fiber size were significantly lower in ob/ob mice compared to wild type littermates, being significantly increased by leptin administration (P |
| وصف الملف: | application/pdf |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec2b23f4ce9b781afe14332e7a0a040 https://doi.org/10.1371/journal.pone.0006808 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bec2b23f4ce9b781afe14332e7a0a040 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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