This chapter presents a summary of major applications in numerical oil spill predictions for the Eastern Mediterranean Sea. Since the trilateral agreement between Cyprus, Egypt, and Israel back in 1997, under the framework of the subregional contingency plan for preparedness and response to major oil spill pollution incidents in the Eastern Mediterranean Sea, several oil spill models have been implemented during real oil pollution accidents and after oil spills that were detected from satellite remote sensing SAR data. In addition, several projects cofinanced by the European Commission addressed particularly issues with oil spill modeling, taking the advantage of developments in operational oceanography, as well as collaboration with the Mediterranean Oceanographic Network for Global Ocean Observing System (MONGOOS), with the European Maritime Safety Agency CleanSeaNet (EMSA-CSN), and Regional Marine Pollution Emergency Response Centre for the Mediterranean Sea (REMPEC). Major oil pollution incidents in the Eastern Mediterranean and the oil spill modeling applications carried out are summarized in this work. Three well-established operational oil spill modeling systems – two of them characterized by different numerical tools MEDSLIK, MEDSLIK II, and the POSEIDON oil spill models – are described in terms of their applicability to real oil spill pollution events, the Lebanon oil pollution crisis in summer 2006, the case Costa Concordia accident, and the spill event associated with the collision of two cargo vessels in the North Aegean Sea in June 2009. Finally, an overview of the present-day capability of Eastern Mediterranean countries in oil spill modeling is provided in this chapter.