Use of Slow-Release Oral Morphine for the Treatment of Opioid Dependence
| العنوان: | Use of Slow-Release Oral Morphine for the Treatment of Opioid Dependence |
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| المؤلفون: | Romana Ortner, Gabriele Fischer, Reinhold Jagsch, D. Kraigher, Wolfgang Gombas, Harald Eder, Andjela Primorac |
| المصدر: | European Addiction Research. 11:145-151 |
| بيانات النشر: | S. Karger AG, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Narcotics, Synthetic opioid, Health (social science), Adolescent, Morphine, business.industry, Administration, Oral, Medicine (miscellaneous), Middle Aged, Opioid-Related Disorders, Treatment satisfaction, Psychiatry and Mental health, Opioid, Maintenance therapy, Delayed-Action Preparations, Anesthesia, medicine, Humans, Female, Oral morphine, business, medicine.drug, Methadone |
| الوصف: | Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study. Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.0) or polysubstance dependence (DSM-IV 304.9). Measurements: Primary outcome measures were the study retention rate, urinalysis for additional illicit consumption other than heroin, cravings and withdrawal symptoms 24 h after the last intake of the medication (duration of action of treatment). Findings: In total, 103 patients completed the study, representing a retention rate of 94%. Patients reported significant improvements in somatic complaints, as well as significant reductions in heroin and cocaine cravings (p < 0.0001) and in additional consumption of cocaine in supervised urinalysis (p = 0.0083). Additional illicit consumption of benzodiazepines remained unchanged. Conclusions: The high study retention rate implies a good acceptance of slow-release acting oral morphine. However, randomised, double-blind, double-dummy studies with a longer investigational period are needed to meet criteria for evidence-based medicine. |
| تدمد: | 1421-9891 1022-6877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf258f80a3e3adc7ce1ae0e49d3022c6 https://doi.org/10.1159/000085550 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bf258f80a3e3adc7ce1ae0e49d3022c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219891 10226877 |
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