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Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study

التفاصيل البيبلوغرافية
العنوان: Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study
المؤلفون: Peer Brehm Christensen, Kirsten Riisom, Niels Obel, Jørgen Georgsen, S. E. H. Jacobsen, Henrik Krarup, Lene Holm Harritshøj, Lars Haukali Omland, Peter Uhd Jepsen, Henrik Toft Sørensen, Per Schouenborg
المصدر: Omland, L H H, Krarup, H B, Jepsen, P, Georgsen, J, Harritshøj, L H, Riisom, K, Jacobsen, S E H, Schouenborg, P, Christensen, P B, Sørensen, H T, Obel, N, DANVIR Cohort Study & Münster, A-M B 2010, ' Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study ', Journal of Hepatology, vol. 53, no. 1, pp. 36-42 . https://doi.org/10.1016/j.jhep.2010.01.033
Omland, L H, Krarup, H, Jepsen, P, Georgsen, J, Harritshøj, L H, Riisom, K, Jacobsen, S E H, Schouenborg, P, Christensen, P B, Sørensen, H T, Obel, N & on behalf of the DANVIR Cohort Study 2010, ' Mortality in patients with chronic and cleared hepatitis C viral infection: A nationwide cohort study ', Journal of Hepatology, vol. 53, no. 1, pp. 36-42 . https://doi.org/10.1016/j.jhep.2010.01.033
سنة النشر: 2009
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, viruses, Hepatitis C virus, Denmark, Hepacivirus, Kaplan-Meier Estimate, medicine.disease_cause, Virus Replication, Cohort Studies, Internal medicine, Epidemiology, medicine, Humans, Hepatology, Proportional hazards model, business.industry, Mortality rate, virus diseases, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Comorbidity, digestive system diseases, Surgery, RNA, Viral, Female, Viral disease, business, Cohort study
الوصف: Udgivelsesdato: 2010-Mar-29 BACKGROUND & AIMS: It is unknown whether mortality differs between patients with chronic hepatitis C virus (HCV) replication and those who cleared the virus after infection. We examined the impact of chronic HCV replication on mortality among Danish patients testing positive for HCV antibodies. METHODS: This nationwide cohort study focused on Danish patients with at least one HCV RNA measurement available after testing positive for HCV antibodies between 1996 and 2005. To capture long-term prognosis, eligible patients needed to be alive 1year after HCV RNA assessment. We estimated mortality rate ratios (MRRs) using Cox regression (for overall mortality) and subdistribution hazard ratios (SDHRs) for cause-specific mortality, controlling for gender, age, comorbidity, calendar period, alcohol abuse, injection drug use and income. RESULTS: Of the 6292 patients under study, 63% had chronic HCV-infection and 37% had cleared the virus. Five-year survival was 86% (95% confidence interval (CI): 84-87%) in the chronic HCV group and 92% (95% CI: 91-94%) in the cleared HCV group. Chronic HCV-infection was associated with higher overall mortality (MRR: 1.55, 95% CI: 1.28-1.86) and liver-related death (SDHR: 2.42, 95% CI: 1.51-3.88). Chronic HCV-infection greatly increased the risk of death from primary liver cancer (SDHR: 16.47, 95% CI: 2.24-121.00). CONCLUSIONS: Patients with chronic HCV-infection are at higher risk of death than patients who cleared the infection. The substantial association found between chronic HCV-infection and death from primary liver cancer supports early initiation of antiviral treatment in chronically HCV-infected patients.
تدمد: 1600-0641
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9ffd33d25e0c595f688a02cf3311aa
https://pubmed.ncbi.nlm.nih.gov/20400197
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....bf9ffd33d25e0c595f688a02cf3311aa
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16000641