HLA-DQA1, DQB1 and DPB1 alleles on HLA-DQ2- and DQ9-carrying extended haplotypes
| العنوان: | HLA-DQA1, DQB1 and DPB1 alleles on HLA-DQ2- and DQ9-carrying extended haplotypes |
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| المؤلفون: | Maria B. Delgado, Chaster A. Alper, Marcala Salazar, Edmond J. Yunis, David H. Bing, Juan J. Yunis |
| المصدر: | Tissue Antigens. 41:37-41 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | HLA-DP Antigens, Extended haplotype, Molecular Sequence Data, Immunology, Population, Human leukocyte antigen, Biology, Major histocompatibility complex, Polymerase Chain Reaction, Biochemistry, HLA-DQ alpha-Chains, Major Histocompatibility Complex, HLA-DQ Antigens, Genetics, HLA-DQ beta-Chains, Humans, Immunology and Allergy, Typing, Allele, education, Alleles, HLA-DP beta-Chains, education.field_of_study, Base Sequence, Haplotype, HLA-DQ2, nutritional and metabolic diseases, General Medicine, Haplotypes, biology.protein, France, Polymorphism, Restriction Fragment Length |
| الوصف: | DQA1, DQB1 and DPB1 alleles were investigated in a large panel of samples carrying HLA-DQ2- and HLA-DQ9-bearing extended haplotypes. Every instance of the [HLA-B8, SCO1, DR3, DQ2a] and [HLA-B18, F1C3, DR3, DQ2b] extended haplotypes carried the DQA1*-0501 allele, while every instance of [HLA-844, F1C31, DR7, DQ2c], (HLA-B47, FC91,0, DR7, DQ2c] and [HLA-B57, SC61, DR7, DQ2d] carried the DQA1*0201 allele. All HLA-DR3, DQ2 and HLA-DR7, DQ2 extended haplotypes carried the DQB1*0201 allele. Every example of [HLA-B57, SC61, DR7, DQ9] carried the DQB1*0303 allele. Several associations between the DPB1 alleles and some HLA-DQ2- and DQ9-carrying extended haplotypes were identified. HLA-DPw2-encoding alleles. DPB1*0202 (50%, p < 0.001) and 0201 (30%). were found on the [HLA-B18, F1C30, DR3, DQ2b] extended haplotype. Every instance of the [HLA-B57, SC61, DR7, DQ9] extended haplotype carried the DPB 1*0401 allele. Also, we have confirmed the associations of the DPB1*0101 and DPB1*0401 alleles with the [HLA-B8, SC01. DR3, DQ2a] extended haplotype. The analysis of hornozygous typing cells carrying the [HLA-B44. FC31, DR7, DQ2c] extended haplotype showed that the DPB1*0401 and 0201 alleles were present at similar frequencies (37.5%). while the DPB1*1101 allele was found in only 25% of these haplotypes analyzed. Our results suggest that the constancy of the DNA of the HLA-B, DR, DQ regions may extend to the DP region and that the extent of such fixity varies, perhaps as the result of ethnic variability of the population studied. |
| تدمد: | 1399-0039 0001-2815 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcced23a406eb5918d782b0b280d4e5 https://doi.org/10.1111/j.1399-0039.1993.tb01975.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bfcced23a406eb5918d782b0b280d4e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990039 00012815 |
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