Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients
| العنوان: | Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients |
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| المؤلفون: | Jerzy Moczko, Jarosław Walkowiak, Philip Grebowiec, Przemysław Mańkowski, Aleksandra Lisowska, Dorota Sands, Beata Krasińska, Edyta Mądry, Sławomira Drzymała-Czyż, Alina Minarowska, Beata Oralewska |
| المصدر: | European Journal of Human Genetics. 20:1092-1095 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, musculoskeletal diseases, Vitamin, medicine.medical_specialty, Malabsorption, Cystic Fibrosis, Bone density, medicine.medical_treatment, Short Report, Polymorphism, Single Nucleotide, Cystic fibrosis, chemistry.chemical_compound, Lactose Intolerance, Bone Density, Risk Factors, Internal medicine, Genetics, medicine, Humans, Child, Promoter Regions, Genetic, Bone Demineralization, Pathologic, Genetics (clinical), Cholecalciferol, Lactase, Calcium metabolism, Lactose intolerance, business.industry, Body Weight, medicine.disease, Endocrinology, Breath Tests, chemistry, Calcium, Female, Steatosis, business |
| الوصف: | As decreased bone mineral density (BMD) is a common problem in cystic fibrosis (CF) and milk products may have pivotal dietary role affecting BMD, we aimed to assess the potential influence of adult-type hypolactasia (ATH) and lactose malabsorption (LM) on BMD in adolescent and young adult patients. In 95 CF pancreatic-insufficient patients aged 10–25 years (without liver cirrhosis, steatosis and cholestasis, diabetes mellitus, systemic glucocorticoid therapy), lumbar BMD, the nutritional status, pulmonary function, vitamin D3 concentration, calcium intake and single-nucleotide polymorphism upstream of the lactase gene were assessed. In subjects with the −13910 C/C genotype predisposing to ATH, the presence of LM was determined with the use of a hydrogen–methane breath test (BT). BMD and calcium intake were significantly lower in patients with the C/C genotype (P |
| تدمد: | 1476-5438 1018-4813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00ea159e3f41495c387baf4e7d976e4 https://doi.org/10.1038/ejhg.2012.52 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c00ea159e3f41495c387baf4e7d976e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765438 10184813 |
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