Tau protein immunoreactivity in muscle fibers with rimmed vacuoles differs from that in regenerating muscle fibers
| العنوان: | Tau protein immunoreactivity in muscle fibers with rimmed vacuoles differs from that in regenerating muscle fibers |
|---|---|
| المؤلفون: | Y. Ihara, Koichi Ishiguro, Ikuya Nonaka, Nobuyuki Murakami, Hideo Sugita, Kazutomo Imahori |
| المصدر: | Acta Neuropathologica. 90:467-471 |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Muscle Fibers, Skeletal, Tau protein, tau Proteins, Vacuole, Biology, Muscular Dystrophies, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Tubulin, Microtubule, medicine, Humans, Regeneration, Child, Myopathy, Muscle biopsy, medicine.diagnostic_test, Rimmed vacuoles, Middle Aged, medicine.disease, Immunohistochemistry, Cell biology, Child, Preschool, Vacuoles, biology.protein, Female, Neurology (clinical), Inclusion body myositis, medicine.symptom |
| الوصف: | To determine whether tau protein found in muscle fibers with rimmed vacuoles and in regenerating fibers was phosphorylated, we examined eight muscle biopsy samples containing rimmed vacuoles (from five patients with distal myopathy with rimmed vacuole formation and three patients with inclusion body myositis) and three muscle biopsy samples from patients with Duchenne muscular dystrophy containing numerous regenerating fibers. Although both rimmed vacuolated and regenerating fibers had increased immunoreactivity against tubulin and tau protein, tau protein in the former was more highly phosphorylated than that in the latter. While very few microtubules in muscle fibers with rimmed vacuoles were recognizable by electron microscopy, regenerating fibers, especially immature ones, contained numerous microtubules. Since tau protein found in vacuolated fibers is hyperphosphorylated, it can be considered to have reduced ability to bind tubulin molecules. Thus, the tau protein cannot stabilize microtubules, resulting in their depolymerization even in the presence of tubulin molecules. |
| تدمد: | 1432-0533 0001-6322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02ff44cb91a2aca1b2f46fb67dedb97 https://doi.org/10.1007/bf00294807 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c02ff44cb91a2aca1b2f46fb67dedb97 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320533 00016322 |
|---|