Early evidence from China suggested that blood groups may be involved in susceptibility to COVID‐19. Several subsequent studies reported controversial results. We conducted a retrospective matched case‐control study that aims to investigate the association between blood groups and the risk and/or severity of COVID‐19. We compared the blood groups distribution of 474 patients admitted to the hospital for COVID‐19 between March 2020 and March 2021, to that of a positive control group of outpatients infected with COVID‐19 and matched them for sex and age, as well as to the distribution in the general population. Three hundred and eighteen HC+ pairs with available blood group information were matched. The proportion of group A Rh+ in hospitalized patients (HC+) was 39.9% (CI 35.2%–44.7%), compared to 44.8% (CI 39.8%–49.9%) and 32.3% in the positive outpatient controls (C+) and the general population (C−), respectively. Both COVID‐19‐positive groups (HC+ and C+) had significantly higher proportions of group A Rh+ compared to the general population (p = 0.0019 and p
