Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder
| العنوان: | Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder |
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| المؤلفون: | Henry W. Chase, Amelia Versace, Simona Graur, Ricki Stiffler, Hesheng Liu, B D Greenberg, Anastasia Yendiki, Suzanne N. Haber, J. P. Lima Santos, S. Rasmussen, Tae Kim, Lisa Bonar, Robert Hudak, Tsafrir Greenberg, Mary L. Phillips |
| المصدر: | Neuropsychopharmacology |
| بيانات النشر: | Springer International Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Obsessive-Compulsive Disorder, Prefrontal Cortex, Review Article, behavioral disciplines and activities, Gyrus Cinguli, Severity of Illness Index, White matter, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Nerve Fibers, Reward, Severity of illness, Fractional anisotropy, Neural Pathways, medicine, Humans, Young adult, Anterior cingulate cortex, Pharmacology, business.industry, Depression, Attentional control, Repeated measures design, Anatomy, Collinearity, White Matter, 030227 psychiatry, Psychiatry and Mental health, medicine.anatomical_structure, Diffusion Tensor Imaging, Anisotropy, Female, business, 030217 neurology & neurosurgery |
| الوصف: | Obsessive-compulsive disorder (OCD) is a disabling condition, often associated with a chronic course. Given its role in attentional control, decision-making, and emotional regulation, the anterior cingulate cortex is considered to have a key role in the pathophysiology of the disorder. Notably, the cingulum bundle, being the major white matter tract connecting to this region, has been historically a target for the surgical treatment of intractable OCD. In this study, we aimed to identify the extent to which focal—more than diffuse—abnormalities in fiber collinearity of the cingulum bundle could distinguish 48 adults with OCD (mean age [SD] = 23.3 [4.5] years; F/M = 30/18) from 45 age- and sex-matched healthy control adults (CONT; mean age [SD] = 23.2 [3.8] years; F/M = 28/17) and further examine if these abnormalities correlated with symptom severity. Use of tract-profiles rather than a conventional diffusion imaging approach allowed us to characterize white matter microstructural properties along (100 segments), as opposed to averaging these measures across, the entire tract. To account for these 100 different segments of the cingulum bundle, a repeated measures analysis of variance revealed a main effect of group (OCD |
| اللغة: | English |
| تدمد: | 1740-634X 0893-133X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04444b478834e71f76b68eeb3c71973 http://europepmc.org/articles/PMC6784994 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c04444b478834e71f76b68eeb3c71973 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1740634X 0893133X |
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