UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
| العنوان: | UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling |
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| المؤلفون: | S Torrino, V Tiroille, B Dolfi, M Dufies, C Hinault, L Bonesso, S Dagnino, JP Uhler, M Irondelle, AS Gay, L Fleuriot, D Debayle, S Lacas-Gervais, M Cormont, T Bertero, F Bost, J Gilleron, S Clavel |
| المساهمون: | Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Centre Scientifique de Monaco (CSM), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), ANR-18-CE14-0025,MatriPHate,Comprendre la dynamique de la niche vasculaire dans l'hypertension pulmonaire.(2018), Centre Hospitalier Universitaire de Nice (CHU Nice), Imperial College London, University of Gothenburg (GU), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Bertero, Thomas, Bost, Frédéric |
| المصدر: | eLife eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.68348⟩ eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.68348⟩ eLife, 2021, 10, ⟨10.7554/elife.68348⟩ eLife, Vol 10 (2021) eLife, 2021, 10, ⟨10.7554/eLife.68348⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Acid Ceramidase, [SDV]Life Sciences [q-bio], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], chemistry.chemical_compound, 0302 clinical medicine, Ubiquitin, Sequestosome-1 Protein, cell biology, Epidermal growth factor receptor, Biology (General), Phosphorylation, 0303 health sciences, education.field_of_study, biology, Neoplasm Proteins, Cell biology, ErbB Receptors, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Medicine, Signal transduction, Signal Transduction, Ceramide, QH301-705.5, Science, EGFR, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Ceramides, ubiquitination, Gene Expression Regulation, Enzymologic, UBTD1, 03 medical and health sciences, Sequestosome 1, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Humans, ceramide, human, education, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Ubiquitins, 030304 developmental biology, Cell growth, Prostatic Neoplasms, Endolysosome, Kinetics, cell proliferation, chemistry, Proteolysis, biology.protein, Lysosomes |
| الوصف: | To adapt in an ever-changing environment, cells must integrate physical and chemical signals and translate them into biological meaningful information through complex signaling pathways. By combining lipidomic and proteomic approaches with functional analysis, we have shown that UBTD1 (Ubiquitin domain-containing protein 1) plays a crucial role in both the EGFR (Epidermal Growth Factor Receptor) self-phosphorylation and its lysosomal degradation. On the one hand, by modulating the cellular level of ceramides through ASAH1 (N-Acylsphingosine Amidohydrolase 1) ubiquitination, UBTD1 controls the ligand-independent phosphorylation of EGFR. On the other hand, UBTD1, via the ubiquitination of SQSTM1/p62 (Sequestosome 1) and endolysosome positioning, participates in the lysosomal degradation of EGFR. The coordination of these two ubiquitin-dependent processes contributes to the control of the duration of the EGFR signal. Moreover, we showed that UBTD1 depletion exacerbates EGFR signaling and induces cell proliferation emphasizing a hitherto unknown function of UBTD1 in EGF-driven cell proliferation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2050-084X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063746d57ffb3738310b2b4cb7ce585 https://hal.archives-ouvertes.fr/hal-03408303/file/elife-68348-v2.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c063746d57ffb3738310b2b4cb7ce585 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
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