Etiopathogenesis of Behçet's disease with emphasison the role of immunological aberrations
| العنوان: | Etiopathogenesis of Behçet's disease with emphasison the role of immunological aberrations |
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| المؤلفون: | Phaedon G. Kaklamanis, Violetta Kapsimali, George Vaiopoulos, Meletios A. Kanakis |
| المصدر: | Clinical Rheumatology. 29:1211-1216 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Neutrophils, T-Lymphocytes, Disease, Behcet's disease, Environment, Pathogenesis, Oral aphthous ulcers, Rheumatology, Internal medicine, medicine, Humans, Thrombophilia, Genetic Predisposition to Disease, Endothelium, Heat-Shock Proteins, Autoantibodies, Inflammation, Helicobacter pylori, business.industry, Behcet Syndrome, General Medicine, medicine.disease, Pathophysiology, Immune System, Immunology, Etiology, Female, business, Inflammatory disorder |
| الوصف: | Behçet's disease (BD) is a chronic multisystemic inflammatory disorder of unknown origin consisting of oral aphthous ulcers, ocular symptoms, skin lesions, and genital ulcerations. It has many features in common with systemic vasculitides and is more prevalent in countries along the ancient Silk route. Immune-mediated mechanisms play a major role in the pathogenesis of the disease, and inflammatory mediators are also involved. BD is not considered to be an autoimmune disorder, and the character of the disease needs to be clarified. Immunological aberrations in BD have been extensively studied by many investigators; genetic factors have been related to disease susceptibility, but their exact role in the development of disease is uncertain. Environmental factors such as infectious agents have also been implicated in the etiology of BD. However, the etiopathogenesis of the disease remains to be elucidated. Factors involved in the immunopathogenesis of BD with emphasis on the role of immunological aberrations are analyzed in this review. |
| تدمد: | 1434-9949 0770-3198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06e09b5a8699cffe7096a70f4ca4a2f https://doi.org/10.1007/s10067-010-1491-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....c06e09b5a8699cffe7096a70f4ca4a2f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14349949 07703198 |
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