Epigenetic factors in the regulation of prospermatogonia and spermatogonial stem cells
| العنوان: | Epigenetic factors in the regulation of prospermatogonia and spermatogonial stem cells |
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| المؤلفون: | Hung-Fu Liao, Yen-Tzu Tseng, Chih-Yun Yu, Chu-Fan Mo, Shau-Ping Lin |
| المصدر: | REPRODUCTION. 150:R77-R91 |
| بيانات النشر: | Bioscientifica, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Embryology, Biology, Cell fate determination, Epigenesis, Genetic, Mice, Endocrinology, medicine, Animals, Humans, Cell Lineage, Gene Silencing, Epigenetics, Cell Self Renewal, Stem Cell Niche, Spermatogenesis, Tissue homeostasis, Epigenomics, Gene Expression Regulation, Developmental, Obstetrics and Gynecology, Cell Biology, Epigenome, Embryonic stem cell, Spermatogonia, Cell biology, Adult Stem Cells, MicroRNAs, medicine.anatomical_structure, Reproductive Medicine, Stem cell, Germ cell, Signal Transduction |
| الوصف: | Appropriate regulation of epigenome within cells is crucial for the determination of cell fate and contributes to the lifelong maintenance of tissue homeostasis. Epigenomic re-establishment during embryonic prospermatogonia development and fine-tune of the epigenetic landscape in postnatal spermatogonial stem cells (SSCs) are two key processes required for functional male germ cell formation. Repression of re-activated transposons and male germline-specific epigenome establishment occur in prospermatogonia, whereas modulations of the epigenetic landscape is important for SSC self-renewal and differentiation to maintain the stem cell pool and support long-term sperm production. Here, we describe the impact of epigenome-related regulators and small non-coding RNAs as well as the influence of epigenome modifications that result from extrinsic signaling for controlling the decision between self-renewal, differentiation and survival in mouse prospermatogonia and SSCs. This article provides a review of epigenome-related molecules involved in cell fate determination in male germ cells and discusses the intriguing questions that arise from these studies. |
| تدمد: | 1741-7899 1470-1626 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ad9f3b825665346818049d70e83fea https://doi.org/10.1530/rep-14-0679 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c0ad9f3b825665346818049d70e83fea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417899 14701626 |
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