Comparison of beta-ligands used in cattle production: structures, safety, and biological effects
| العنوان: | Comparison of beta-ligands used in cattle production: structures, safety, and biological effects |
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| المؤلفون: | Paul Brent, Richard L. Ellis, Bradley J. Johnson, Anna C Dilger |
| المصدر: | Journal of Animal Science |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Meat, 010504 meteorology & atmospheric sciences, Functional features, Population, Biology, Ligands, Weight Gain, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Carcass weight, Receptors, Adrenergic, beta, Genetics, Production (economics), Animals, education, Beta (finance), Featured Collection, 0105 earth and related environmental sciences, education.field_of_study, business.industry, Zilpaterol, zilpaterol, General Medicine, Adrenergic beta-Agonists, Food safety, beta-ligand, Biotechnology, Ractopamine, food safety, chemistry, cattle, lubabegron, ractopamine, AcademicSubjects/SCI00960, Animal Science and Zoology, Board Invited Review, business, 030217 neurology & neurosurgery, Food Science |
| الوصف: | Technologies that increase the efficiency and sustainability of food animal production to provide meat for a growing population are necessary and must be used in a manner consistent with good veterinary practices, approved labeled use, and environmental stewardship. Compounds that bind to beta-adrenergic receptors (β-AR), termed beta-adrenergic receptor ligands (β-ligands), are one such technology and have been in use globally for many years. Though all β-ligands share some similarities in structure and function, the significance of their structural and pharmacological differences is sometimes overlooked. Structural variations in these molecules can affect absorption, distribution, metabolism, and excretion as well as cause substantial differences in biological and metabolic effects. Several β-ligands are available for use specifically in cattle production. Ractopamine and zilpaterol are beta-adrenergic agonists approved to increase weight gain, feed efficiency, and carcass leanness in cattle. They both bind to and activate β1- and β2-AR. Lubabegron is a newly developed selective beta-adrenergic modulator with unique structural and functional features. Lubabegron displays antagonistic behavior at the β1- and β2-AR but agonistic behavior at the β3-AR. Lubabegron is approved for use in cattle to reduce ammonia emissions per unit of live or carcass weight. Additionally, lubabegron can withstand prolonged use as the β3-AR lacks structural features needed for desensitization. Due to these unique features of lubabegron, this new β-ligand provides an additional option in cattle production. The individual properties of each β-ligand should be considered when making risk management decisions, as unique properties result in varying human food safety profiles that can determine appropriate safe β-ligand use. |
| اللغة: | English |
| تدمد: | 1525-3163 0021-8812 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aed3d260d5ae775e84b27789f1d012 http://europepmc.org/articles/PMC8326055 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c0aed3d260d5ae775e84b27789f1d012 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15253163 00218812 |
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