Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks
| العنوان: | Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks |
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| المؤلفون: | Jed A. Fuhrman, Jake L. Weissman, Sean Meaden, Edze R. Westra, Ellinor O. Alseth |
| المصدر: | Proceedings of the Royal Society B: Biological Sciences |
| بيانات النشر: | The Royal Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lag, Viral challenge, Computational biology, General Biochemistry, Genetics and Molecular Biology, Disease Outbreaks, Bacteriophage, Immune system, bacteriophage, CRISPR, Bacteriophages, CRISPR-Cas, Research Articles, General Environmental Science, Genetics, Bacteria, Ecology, General Immunology and Microbiology, biology, Outbreak, adaptive immunity, General Medicine, biology.organism_classification, Acquired immune system, Archaea, host–virus interactions, Viruses, CRISPR-Cas Systems, General Agricultural and Biological Sciences |
| الوصف: | Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptive immune systems enable bacteria and archaea to efficiently respond to viral pathogens by creating a genomic record of previous encounters. These systems are broadly distributed across prokaryotic taxa, yet are surprisingly absent in a majority of organisms, suggesting that the benefits of adaptive immunity frequently do not outweigh the costs. Here, combining experiments and models, we show that a delayed immune response which allows viruses to transiently redirect cellular resources to reproduction, which we call ‘immune lag’, is extremely costly during viral outbreaks, even to completely immune hosts. Critically, the costs of lag are only revealed by examining the early, transient dynamics of a host–virus system occurring immediately after viral challenge. Lag is a basic parameter of microbial defence, relevant to all intracellular, post-infection antiviral defence systems, that has to-date been largely ignored by theoretical and experimental treatments of host-phage systems. |
| تدمد: | 1471-2954 0962-8452 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0daf8453108c1611e4601f9d5e4eb51 https://doi.org/10.1098/rspb.2021.1555 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c0daf8453108c1611e4601f9d5e4eb51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712954 09628452 |
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