Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study
| العنوان: | Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study |
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| المؤلفون: | Alexander Burkhardt, Leonie Brinkmann, Bettina Gathmann, Katharina Feldker, Christine Buff, David Hofmann, Thomas Straube |
| المصدر: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| بيانات النشر: | Nature Publishing Group UK, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Imagery, Psychotherapy, Emotions, lcsh:Medicine, Prefrontal Cortex, Pilot Projects, Audiology, Brain mapping, Amygdala, behavioral disciplines and activities, Gyrus Cinguli, Article, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, medicine, Humans, lcsh:Science, Prefrontal cortex, Anterior cingulate cortex, Neural correlates of consciousness, Brain Mapping, Multidisciplinary, medicine.diagnostic_test, business.industry, Panic disorder, lcsh:R, Brain, Fear, medicine.disease, Anxiety Disorders, Magnetic Resonance Imaging, 030104 developmental biology, medicine.anatomical_structure, Imagination, Anxiety, Panic Disorder, lcsh:Q, Female, medicine.symptom, business, Functional magnetic resonance imaging, 030217 neurology & neurosurgery |
| الوصف: | Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery of disorder-specific situations proved to be a powerful tool to investigate dysfunctional threat processing in anxiety disorders. The current functional magnetic resonance imaging (fMRI) study aimed at investigating brain activation in PD patients during disorder-related script-driven imagery. Seventeen PD patients and seventeen healthy controls (HC) were exposed to newly developed disorder-related and neutral narrative scripts while brain activation was measured with fMRI. Participants were encouraged to imagine the narrative scripts as vividly as possible and they rated their script-induced emotional states after the scanning session. PD patients rated disorder-related scripts as more arousing, unpleasant and anxiety-inducing as compared to HC. Patients relative to HC showed elevated activity in the right amygdala and the brainstem as well as decreased activity in the rostral anterior cingulate cortex, and the medial and lateral prefrontal cortex to disorder-related vs. neutral scripts. The results suggest altered amygdala/ brainstem and prefrontal cortex engagement and point towards the recruitment of brain networks with opposed activation patterns in PD patients during script-driven imagery. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10bfe0d8b2d954e31187070e91b7716 http://europepmc.org/articles/PMC6382839 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c10bfe0d8b2d954e31187070e91b7716 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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