Antiproliferative polycyclic polyprenylated acylphloroglucinols from Garcinia paucinervis
| العنوان: | Antiproliferative polycyclic polyprenylated acylphloroglucinols from Garcinia paucinervis |
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| المؤلفون: | Cui-Cui Jia, Jing-Jing Xue, Zhan-Lin Li, Da-Hong Li, Hui-Ming Hua |
| المصدر: | Natural Product Research. :1-8 |
| بيانات النشر: | Informa UK Limited, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry |
| الوصف: | Bioassay-guided isolation of the stems of Garcinia paucinervis led to one new adamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), (-)-garpauvinin A (1), and four known analogues (2–5). The structure and absolute configuration of 1 was established via spectroscopic techniques and ECD method. All the isolates displayed moderate antiproliferative activity against HL-60, PC-3 and Caco-2 human cancer cell lines with IC50 values ranging from 0.81 to 19.92 μM, and exhibited low toxicity on WPMY-1 normal human cells, showing selectivity between normal and malignant prostate cells. The biosynthetic pathways of the isolated PPAPs were proposed. |
| تدمد: | 1478-6427 1478-6419 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c125fd7c1a6270e5437d0f4baec82b89 https://doi.org/10.1080/14786419.2023.2217469 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c125fd7c1a6270e5437d0f4baec82b89 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14786427 14786419 |
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