Bacterial zinc uptake regulator proteins and their regulons
| العنوان: | Bacterial zinc uptake regulator proteins and their regulons |
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| المؤلفون: | Alevtina Mikhaylina, Amira Z. Ksibe, David J. Scanlan, Claudia A. Blindauer |
| المصدر: | Biochemical Society Transactions |
| بيانات النشر: | Portland Press Ltd., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Protein Conformation, 030106 microbiology, Regulator, zinc-responsive transcription factors, Virulence, Review Article, Biochemistry, Regulon, 03 medical and health sciences, Structure-Activity Relationship, Bacterial Proteins, Ribosomal protein, Transcription (biology), Homeostasis, Amino Acid Sequence, Gene, Transcription factor, Review Articles, zinc uptake regulator, Bacteria, Sequence Homology, Amino Acid, Chemistry, metal ions, Zur, Cell biology, Zinc, Efflux |
| الوصف: | All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of essential elements, including d-block metal ions. In bacteria, such regulation is achieved by the action of metal-responsive transcriptional regulators. Among several families of zinc-responsive transcription factors, the ‘zinc uptake regulator’ Zur is the most widespread. Zur normally represses transcription in its zinc-bound form, in which DNA-binding affinity is enhanced allosterically. Experimental and bioinformatic searches for Zur-regulated genes have revealed that in many cases, Zur proteins govern zinc homeostasis in a much more profound way than merely through the expression of uptake systems. Zur regulons also comprise biosynthetic clusters for metallophore synthesis, ribosomal proteins, enzymes, and virulence factors. In recognition of the importance of zinc homeostasis at the host–pathogen interface, studying Zur regulons of pathogenic bacteria is a particularly active current research area. |
| اللغة: | English |
| تدمد: | 1470-8752 0300-5127 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c133c46e8f3755e05976ccc6be05d3be http://europepmc.org/articles/PMC6103462 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c133c46e8f3755e05976ccc6be05d3be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708752 03005127 |
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