Reduced antibiotic use after initial treatment of acute respiratory infections with phytopharmaceuticals- a retrospective cohort study
| العنوان: | Reduced antibiotic use after initial treatment of acute respiratory infections with phytopharmaceuticals- a retrospective cohort study |
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| المؤلفون: | Marcel Konrad, Karel Kostev, Charles Christian Adarkwah, David Martin |
| المصدر: | Postgraduate Medicine. 132:412-418 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, medicine.drug_class, Antibiotics, chemical and pharmacologic phenomena, 030209 endocrinology & metabolism, Comorbidity, Disease, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Internal medicine, Humans, Medicine, Initial treatment, Practice Patterns, Physicians', Respiratory system, Antibiotic use, Respiratory Tract Infections, Retrospective Studies, Plant Extracts, business.industry, Age Factors, hemic and immune systems, Retrospective cohort study, General Medicine, Middle Aged, Anti-Bacterial Agents, Logistic Models, Socioeconomic Factors, Upper tract, Acute Disease, Sick leave, Drug Therapy, Combination, Female, Sick Leave, business, Phytotherapy |
| الوصف: | We examined the relationship between the initial treatment of acute lower and upper tract respiratory infections with phytopharmaceuticals and the duration of the disease as well as between the initial treatment and the use of antibiotics in the further course of the disease.Outpatients from the IMS® Disease Analyzer database with diagnoses of acute respiratory infections between January 2015 and March 2019 were observed for 30 days. Patients who had been prescribed phytopharmaceuticals on the day of their diagnosis were matched with controls who had not received such prescriptions by treating practice, diagnosis, age, sex, insurance status, index year, and Charlson comorbidity score. Patients antibiotic precriptions on the day of diagnosis were excluded. Logistic regression was used to investigate the relationship between phytopharmaceutical prescription, antibiotic prescription in the further course of the disease, and duration of sick leave.A total of 117,182 patients who had been prescribed phytopharmaceuticals and an equal number of controls were available for analysis. Phytotherapeutics were associated with fewer antibiotic prescriptions. Extract of Pelargonium sidoides root (odds ratio (OR) 0.49 [0.43-0.57]) and thyme extract (OR 0.62 [0.49-0.76]) exhibited the strongest effect among patients treated by general practitioners, while Pelargonium sidoides root extract (OR 0.57 [0.38-0.84]), thyme and ivy extract (OR 0.66 [0.60-0.73]), and thyme and primrose root extract (OR 0.67 [0.47-0.96]) proved most effective in pediatric patients. Patients receiving phytopharmaceuticals had a significantly lower risk of prolonged periods of sick leave. The risk of sick leave durations of7 days was most markedly reduced in patients taking cineole (OR 0.74 [0.63-0.86]) and Pelargonium root extract (OR 0.79 [0.54-0.96]).The use of selected phytopharmaceuticals for acute respiratory infections is associated with a significantly reduced need for antibiotic prescriptions in the further course of the disease, as well as significantly shorter sick leaves. |
| تدمد: | 1941-9260 0032-5481 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13bb48cba140c7213ecc9da76128aa2 https://doi.org/10.1080/00325481.2020.1751497 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c13bb48cba140c7213ecc9da76128aa2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 19419260 00325481 |
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